GL-V9 ameliorates liver fibrosis by inhibiting TGF-O/smad pathway

被引：11
作者：
Guo, Yabing [1 ]
Tian, Geng [2 ]
Chen, Xin [2 ]
Hou, Yingjian [3 ]
Zhang, Xinyu [2 ]
Xue, Xin [2 ]
Zhao, Li [2 ]
Wu, Yun [4 ]
机构：
[1] China Pharmaceut Univ, Pharmaceut Anim Expt Ctr, Nanjing 211198, Peoples R China
[2] China Pharmaceut Univ, Pathol & Patient Derived Xenograft Efficacy Evalua, Sch Basic Med & Clin Pharm, Nanjing 211198, Peoples R China
[3] China Pharmaceut Univ, Ctr Cellular & Mol Biol, Nanjing 211198, Peoples R China
[4] Nanjing Med Univ, Yancheng Peoples Hosp 3, Yancheng Sch Clin Med, Yancheng 224001, Peoples R China
来源：
EXPERIMENTAL CELL RESEARCH | 2023年 / 425卷 / 01期
关键词：
GL-V9; Liver fibrosis; TGF-O; Smad pathway; HEPATIC STELLATE CELLS; ACTIVATION; RESISTANCE; BETA; MYOFIBROBLASTS; TRANSLOCATION; MECHANISMS; RESOLUTION; REVERSES; CONFERS;
D O I：
10.1016/j.yexcr.2023.113521
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Liver fibrosis is a wound-healing response that arises from various aetiologies. Flavonoid compounds have been proved of their anti-liver fibrosis effects. This study aimed to elucidate the protective effect and mechanism of flavonoid compound GL-V9 on CCl4-induced and DDC-induced liver fibrosis. Treatment with GL-V9 alleviated hepatic injury and exhibited a dramatic protection effect of liver fibrosis. Further experiments found that GL-V9 treatment inhibited extracellular matrix (ECM) expression. Activation of hepatic stellate cells (HSCs) is a central driver of fibrosis. GL-V9 could inhibit the activation of HSCs through directly binding to TGFORI, subsequently inhibit TGF-O/Smad pathway. In conclusion, this study proved that GL-V9 executed a protective effect on liver fibrosis by inhibiting TGF-O/Smad pathway.
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页数：9
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