Circular RNA in Retina: a potential biomarker and therapeutic target

被引：5

作者：

Tian, Huiwen ^{[1
]}

Zhao, Lu ^{[1
]}

Li, Hongyang ^{[1
]}

Huang, Yingxiang ^{[1
]}

Wang, Yanling ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Friendship Hosp, Dept Ophthalmol, 95 Yongan Rd, Beijing 100050, Peoples R China

来源：

OPHTHALMIC RESEARCH | 2023年 / 66卷 / 01期

关键词：

RETINOBLASTOMA; PROGRESSION; EXPRESSION; CANCER; ASSOCIATION; DYSFUNCTION; PERICYTES; ROLES;

D O I：

10.1159/000529207

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Circular RNA (circRNA) is a newly discovered non-coding RNA, which forms a closed ring with more than 200 bases in length. CircRNA is formed by back splicing of precursor RNA, and its expression abundance in body fluid is up to 10 times that of homologous linear transcripts. Recently, novel activities for circRNA in various diseases have emerged, ranging from cancer therapy and neurodegenerative diseases. Here, we reviewed the literature on the biogenesis of circrna and its relationship with retinal diseases in recent years. We first described the mechanism, existing form and main function of circRNA. Next, we also pinpoint that circRNA has great value in the diagnosis and treatment of retinal diseases represented by retinoblastoma, retinal degeneration and diabetic retinopathy. By this review, we hope to explore more possibilities of circRNA in clinical diagnosis and treatment.

引用

页码：516 / 528

页数：13

共 87 条

[21] Vascular endothelium in diabetes [J].

Goligorsky, Michael S. .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2017, 312 (02) :F266-F275

[22] RNA in cancer [J].

Goodall, Gregory J. ;

Wickramasinghe, Vihandha O. .

NATURE REVIEWS CANCER, 2021, 21 (01) :22-36

[23] Comprehensive analysis of circular RNA profiles in skeletal muscles of aging mice and after aerobic exercise intervention [J].

Guo, Mingwei ;

Qiu, Jin ;

Shen, Fei ;

Wang, Sainan ;

Yu, Jian ;

Zuo, Hui ;

Yao, Jing ;

Xu, Sainan ;

Hu, Tianhui ;

Wang, Dongmei ;

Zhao, Yu ;

Hu, Yepeng ;

Shen, Feixia ;

Ma, Xinran ;

Lu, Jian ;

Gu, Xuejiang ;

Xu, Lingyan .

AGING-US, 2020, 12 (06) :5071-5090

[24] Circular RNA and its mechanisms in disease: From the bench to the clinic [J].

Han, Bing ;

Chao, Jie ;

Yao, Honghong .

PHARMACOLOGY & THERAPEUTICS, 2018, 187 :31-44

[25]

Han JD, 2017, MOL VIS, V23, P457

[26] Comparison of expression profiling of circular RNAs in vitreous humour between diabetic retinopathy and non-diabetes mellitus patients [J].

He, Miao ;

Wang, Wei ;

Yu, Honghua ;

Wang, Decai ;

Cao, Dan ;

Zeng, Yunkao ;

Wu, Qiaowei ;

Zhong, Pingting ;

Cheng, Zhixing ;

Hu, Yunyan ;

Zhang, Liang .

ACTA DIABETOLOGICA, 2020, 57 (04) :479-489

[27] Functional architecture of the retina: Development and disease [J].

Hoon, Mrinalini ;

Okawa, Haruhisa ;

Della Santina, Luca ;

Wong, Rachel O. L. .

PROGRESS IN RETINAL AND EYE RESEARCH, 2014, 42 :44-84

[28] Pericyte-Endothelial Interactions in the Retinal Microvasculature [J].

Huang, Hu .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (19) :1-18

[29]

Idrees Sana, 2019, Int Ophthalmol Clin, V59, P221, DOI [10.1097/iio.0000000000000258, 10.1097/IIO.0000000000000258]

[30] Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction [J].

Jiang, Qin ;

Liu, Chang ;

Li, Chao-Peng ;

Xu, Shan-Shan ;

Yao, Mu-Di ;

Ge, Hui-Min ;

Sun, Ya-Nan ;

Li, Xiu-Miao ;

Zhang, Shu-Jie ;

Shan, Kun ;

Liu, Bai-Hui ;

Yao, Jin ;

Zhao, Chen ;

Yan, Biao .

JOURNAL OF CLINICAL INVESTIGATION, 2020, 130 (07) :3833-3847

← 1 2 3 4 5 6 7 8 9 →