Xylitol attenuates diabetes induced intestinal permeability changes and inflammatory injury by improving intestinal tight junction protein expression and mucus secretion in rats

被引：1
|
作者：
Han, Feifei [1 ]
Li, Xiang [1 ]
Jin, Yuqi [1 ]
Zuo, Qile [2 ]
Liu, Weilin [1 ]
Han, Jianzhong [1 ,3 ]
机构：
[1] Zhejiang Gongshang Univ, Sch Food Sci & Biotechnol, Food Safety Key Lab Zhejiang Prov, Hangzhou, Peoples R China
[2] Zhejiang Huakang Pharmaceut Co Ltd, Kaihua, Peoples R China
[3] Zhejiang Gongshang Univ, Sch Food Sci & Biotechnol, Food Safety Key Lab Zhejiang Prov, Hangzhou 310018, Peoples R China
来源：
CYTA-JOURNAL OF FOOD | 2024年 / 22卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Xylitol; type; 2; diabetes; intestinal permeability; inflammatory injury; mucus; tight junction protein; SUGAR; LIPOPOLYSACCHARIDE; PARAMETERS; INSULIN; GLUCOSE;
D O I：
10.1080/19476337.2024.2303447
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
The purpose of this study was to investigate the protective effect of xylitol on gut mucosal barrier injury in a type 2 diabetes rat model. Treatment with xylitol not only ameliorated diabetic-induced changes to small intestinal mucosa morphology and decreased diamine oxidase concentration in the serum of diabetic rats, but also modified the inflammatory infiltrates and improved the secretory IgA levels of the small intestinal epithelium. Increased expression of zo-1, occludin, mucin-2 and intestinal trefoil factor also was detected in small intestinal tissue. Intragastric administration of xylitol suppressed diabetes-induced increases of myeloperoxidase, eosinophil peroxidase, IL-6 and TNF-alpha. These results suggest that xylitol reduces mucosal inflammatory lesions and improves the intestinal barrier in diabetic rats by maintaining the structural integrity of the mucous layer, inhibiting the expression of inflammatory mediators and enhancing the expression of tight junction proteins associated with intestinal permeability.
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页数：11
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