In the last three decades, there has been a considerable improvement in human immunodeficiency virus (HIV) therapy. Acquired immunodeficiency syndrome (AIDS) is no longer a common cause of death for people living with HIV (PLWH) in developed countries, and co-infections with hepatitis viruses can be effectively managed. However, metabolic syndrome and metabolic dysfunction-associated steatotic liver disease (MASLD) are emerging threats these days, especially as the HIV-positive population gets older. The factors for MASLD development in PLWH are numerous, including non-specific (common for both HIV-positive and negative) and virus-specific. We focus on what is known for both, and in particular, on the burden of antiretroviral therapy (ART) for metabolic health and liver damage. We review data on contemporary drugs, including different groups and some particular agents in those groups. Among current ART regimens, the switch from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide fumarate (TAF) and particularly its combination with integrase inhibitors (INSTIs) appear to have the most significant impact on metabolic disturbances by increasing insulin resistance, which over the years promotes the evolution of the cascade leading to metabolic syndrome (MetS), MASLD, and eventually metabolic dysfunction-associated steatohepatitis (MASH).
机构:
Massachusetts Gen Hosp, Metab Unit, 5 Longfellow Pl, Boston, MA 02114 USA
Harvard Med Sch, 5 Longfellow Pl, Boston, MA 02114 USAMassachusetts Gen Hosp, Metab Unit, 5 Longfellow Pl, Boston, MA 02114 USA
机构:
Addis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Mafia Dist Hosp, Mafia Isl, TanzaniaAddis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Kajogoo, Violet Dismas
;
Gorret Atim, Mary
论文数: 0引用数: 0
h-index: 0
机构:
Addis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Busitema Univ, Fac Hlth Sci, Mbale, UgandaAddis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Gorret Atim, Mary
;
Amare, Demeke
论文数: 0引用数: 0
h-index: 0
机构:
Addis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Ethiopian Food & Drug Adm Author EFDA, Addis Ababa, EthiopiaAddis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Amare, Demeke
;
Geleta, Melka
论文数: 0引用数: 0
h-index: 0
机构:
Addis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Fed Minist Hlth, Addis Ababa, EthiopiaAddis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Geleta, Melka
;
Muchie, Yilkal
论文数: 0引用数: 0
h-index: 0
机构:
Addis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
All Africa TB Leprosy Training & Rehabil ALERT Ct, Addis Ababa, EthiopiaAddis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Muchie, Yilkal
;
Tesfahunei, Hanna Amanuel
论文数: 0引用数: 0
h-index: 0
机构:
Addis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Hager Biomed Res Inst, Asmera, EritreaAddis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Tesfahunei, Hanna Amanuel
;
Olomi, Willyhelmina
论文数: 0引用数: 0
h-index: 0
机构:
NIMR Mbeya Med Res Program MMRP, Mbeya, TanzaniaAddis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Olomi, Willyhelmina
;
Acam, Joan
论文数: 0引用数: 0
h-index: 0
机构:
Addis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Pope Johns Hosp ABER, Lira Municipality, UgandaAddis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Acam, Joan
;
Manyazewal, Tsegahun
论文数: 0引用数: 0
h-index: 0
机构:
Addis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, EthiopiaAddis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
机构:
Vanderbilt Univ, Med Ctr, Div Infect Dis, Nashville, TN USAVanderbilt Univ, Med Ctr, Div Infect Dis, Nashville, TN USA
Koethe, John R.
;
Lagathu, Claire
论文数: 0引用数: 0
h-index: 0
机构:
Sorbonne Univ, Fac Med, Inserm UMR S938, St Antoine Res Ctr,FRM EQU201903007868,ICAN RHU C, Paris, FranceVanderbilt Univ, Med Ctr, Div Infect Dis, Nashville, TN USA
Lagathu, Claire
;
Lake, Jordan E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Hlth Sci Ctr Houston, Dept Med, Houston, TX 77030 USAVanderbilt Univ, Med Ctr, Div Infect Dis, Nashville, TN USA
Lake, Jordan E.
;
Domingo, Pere
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Santa Creu & Sant Pau, HIV Infect Unit, Dept Infect Dis, Barcelona, SpainVanderbilt Univ, Med Ctr, Div Infect Dis, Nashville, TN USA
Domingo, Pere
;
论文数: 引用数:
h-index:
机构:
Calmy, Alexandra
;
Falutz, Julian
论文数: 0引用数: 0
h-index: 0
机构:
McGill Univ, Hlth Ctr, Dept Med, Montreal, PQ, CanadaVanderbilt Univ, Med Ctr, Div Infect Dis, Nashville, TN USA
Falutz, Julian
;
Brown, Todd T.
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Div Endocrinol Diabet & Metab, Baltimore, MD USAVanderbilt Univ, Med Ctr, Div Infect Dis, Nashville, TN USA
Brown, Todd T.
;
Capeau, Jacqueline
论文数: 0引用数: 0
h-index: 0
机构:
Sorbonne Univ, Fac Med, Inserm UMR S938, St Antoine Res Ctr,FRM EQU201903007868,ICAN RHU C, Paris, FranceVanderbilt Univ, Med Ctr, Div Infect Dis, Nashville, TN USA
机构:
Northwestern Univ, Dept Med, Div Gastroenterol & Hepatol, Chicago, IL 60611 USANorthwestern Univ, Dept Med, Div Gastroenterol & Hepatol, Chicago, IL 60611 USA
Kulik, Laura
;
El-Serag, Hashem B.
论文数: 0引用数: 0
h-index: 0
机构:
Baylor Coll Med, Dept Med, Sect Gastroenterol & Hepatol, Houston, TX 77030 USA
Michael E DeBakey VA Med Ctr, Houston, TX USANorthwestern Univ, Dept Med, Div Gastroenterol & Hepatol, Chicago, IL 60611 USA
机构:
Massachusetts Gen Hosp, Metab Unit, 5 Longfellow Pl, Boston, MA 02114 USA
Harvard Med Sch, 5 Longfellow Pl, Boston, MA 02114 USAMassachusetts Gen Hosp, Metab Unit, 5 Longfellow Pl, Boston, MA 02114 USA
机构:
Addis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Mafia Dist Hosp, Mafia Isl, TanzaniaAddis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Kajogoo, Violet Dismas
;
Gorret Atim, Mary
论文数: 0引用数: 0
h-index: 0
机构:
Addis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Busitema Univ, Fac Hlth Sci, Mbale, UgandaAddis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Gorret Atim, Mary
;
Amare, Demeke
论文数: 0引用数: 0
h-index: 0
机构:
Addis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Ethiopian Food & Drug Adm Author EFDA, Addis Ababa, EthiopiaAddis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Amare, Demeke
;
Geleta, Melka
论文数: 0引用数: 0
h-index: 0
机构:
Addis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Fed Minist Hlth, Addis Ababa, EthiopiaAddis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Geleta, Melka
;
Muchie, Yilkal
论文数: 0引用数: 0
h-index: 0
机构:
Addis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
All Africa TB Leprosy Training & Rehabil ALERT Ct, Addis Ababa, EthiopiaAddis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Muchie, Yilkal
;
Tesfahunei, Hanna Amanuel
论文数: 0引用数: 0
h-index: 0
机构:
Addis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Hager Biomed Res Inst, Asmera, EritreaAddis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Tesfahunei, Hanna Amanuel
;
Olomi, Willyhelmina
论文数: 0引用数: 0
h-index: 0
机构:
NIMR Mbeya Med Res Program MMRP, Mbeya, TanzaniaAddis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Olomi, Willyhelmina
;
Acam, Joan
论文数: 0引用数: 0
h-index: 0
机构:
Addis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Pope Johns Hosp ABER, Lira Municipality, UgandaAddis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
Acam, Joan
;
Manyazewal, Tsegahun
论文数: 0引用数: 0
h-index: 0
机构:
Addis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, EthiopiaAddis Ababa Univ, Coll Hlth Sci, Ctr Innovat Drug Dev & Therapeut Trial Africa CDT, Addis Ababa, Ethiopia
机构:
Vanderbilt Univ, Med Ctr, Div Infect Dis, Nashville, TN USAVanderbilt Univ, Med Ctr, Div Infect Dis, Nashville, TN USA
Koethe, John R.
;
Lagathu, Claire
论文数: 0引用数: 0
h-index: 0
机构:
Sorbonne Univ, Fac Med, Inserm UMR S938, St Antoine Res Ctr,FRM EQU201903007868,ICAN RHU C, Paris, FranceVanderbilt Univ, Med Ctr, Div Infect Dis, Nashville, TN USA
Lagathu, Claire
;
Lake, Jordan E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Hlth Sci Ctr Houston, Dept Med, Houston, TX 77030 USAVanderbilt Univ, Med Ctr, Div Infect Dis, Nashville, TN USA
Lake, Jordan E.
;
Domingo, Pere
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Santa Creu & Sant Pau, HIV Infect Unit, Dept Infect Dis, Barcelona, SpainVanderbilt Univ, Med Ctr, Div Infect Dis, Nashville, TN USA
Domingo, Pere
;
论文数: 引用数:
h-index:
机构:
Calmy, Alexandra
;
Falutz, Julian
论文数: 0引用数: 0
h-index: 0
机构:
McGill Univ, Hlth Ctr, Dept Med, Montreal, PQ, CanadaVanderbilt Univ, Med Ctr, Div Infect Dis, Nashville, TN USA
Falutz, Julian
;
Brown, Todd T.
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Div Endocrinol Diabet & Metab, Baltimore, MD USAVanderbilt Univ, Med Ctr, Div Infect Dis, Nashville, TN USA
Brown, Todd T.
;
Capeau, Jacqueline
论文数: 0引用数: 0
h-index: 0
机构:
Sorbonne Univ, Fac Med, Inserm UMR S938, St Antoine Res Ctr,FRM EQU201903007868,ICAN RHU C, Paris, FranceVanderbilt Univ, Med Ctr, Div Infect Dis, Nashville, TN USA
机构:
Northwestern Univ, Dept Med, Div Gastroenterol & Hepatol, Chicago, IL 60611 USANorthwestern Univ, Dept Med, Div Gastroenterol & Hepatol, Chicago, IL 60611 USA
Kulik, Laura
;
El-Serag, Hashem B.
论文数: 0引用数: 0
h-index: 0
机构:
Baylor Coll Med, Dept Med, Sect Gastroenterol & Hepatol, Houston, TX 77030 USA
Michael E DeBakey VA Med Ctr, Houston, TX USANorthwestern Univ, Dept Med, Div Gastroenterol & Hepatol, Chicago, IL 60611 USA