GLP-1 Analogs, SGLT-2, and DPP-4 Inhibitors: A Triad of Hope for Alzheimer's Disease Therapy

被引：15

作者：

Zlotek, Magdalena ^{[1
]}

Kurowska, Antonina ^{[1
]}

Herbet, Mariola ^{[1
]}

Piatkowska-Chmiel, Iwona ^{[1
]}

机构：

[1] Med Univ Lublin, Fac Pharm, Dept Toxicol, Jaczewskiego 8b St, PL-20090 Lublin, Poland

来源：

BIOMEDICINES | 2023年 / 11卷 / 11期

关键词：

Alzheimer's disease; antidiabetic drugs; neuroprotection; GLP-1; analogs; DPP-4; inhibitors; SGLT-2; GLUCAGON-LIKE PEPTIDE-1; COTRANSPORTER; 2; INHIBITORS; BLOOD-BRAIN-BARRIER; PREVENTS TAU HYPERPHOSPHORYLATION; POSITRON-EMISSION-TOMOGRAPHY; OXIDATIVE STRESS; AMYLOID-BETA; DIPEPTIDYL PEPTIDASE-4; INSULIN-RESISTANCE; RECEPTOR AGONIST;

D O I：

10.3390/biomedicines11113035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alzheimer's is a prevalent, progressive neurodegenerative disease marked by cognitive decline and memory loss. The disease's development involves various pathomechanisms, including amyloid-beta accumulation, neurofibrillary tangles, oxidative stress, inflammation, and mitochondrial dysfunction. Recent research suggests that antidiabetic drugs may enhance neuronal survival and cognitive function in diabetes. Given the well-documented correlation between diabetes and Alzheimer's disease and the potential shared mechanisms, this review aimed to comprehensively assess the potential of new-generation anti-diabetic drugs, such as GLP-1 analogs, SGLT-2 inhibitors, and DPP-4 inhibitors, as promising therapeutic approaches for Alzheimer's disease. This review aims to comprehensively assess the potential therapeutic applications of novel-generation antidiabetic drugs, including GLP-1 analogs, SGLT-2 inhibitors, and DPP-4 inhibitors, in the context of Alzheimer's disease. In our considered opinion, antidiabetic drugs offer a promising avenue for groundbreaking developments and have the potential to revolutionize the landscape of Alzheimer's disease treatment.

引用

页数：34

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