Appropriateness of inpatient intravenous iron therapy in a Swiss tertiary care hospital

被引:0
作者
Ritter, Fabian [1 ,2 ]
Staub, Benjamin M. [1 ]
Osthoff, Michael [1 ,3 ,4 ]
机构
[1] Univ Hosp Basel, Div Internal Med, Basel, Switzerland
[2] Kantonsspital Baselland, Div Internal Med, Liestal, Switzerland
[3] Kantonsspital Winterthur, Div Internal Med, Brauerstr 15, CH-8401 Winterthur, Switzerland
[4] Univ Basel, Dept Clin Res, Basel, Switzerland
关键词
anemia; ferric carboxymaltose; intravenous; iron deficiency; quality control; RANDOMIZED CONTROLLED-TRIAL; DEFICIENCY ANEMIA; ORAL IRON; FERRIC CARBOXYMALTOSE; OPEN-LABEL; MANAGEMENT; HYPOPHOSPHATEMIA; CONSENSUS; SAFETY;
D O I
10.1111/ejh.14053
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Intravenous (IV) iron replacement is an established treatment for iron deficiency and is recommended in various medical guidelines, but cheaper oral iron formulations remain first-line therapy in several instances. Data on adherence to current prescription standards are lacking in Switzerland.Methods: Retrospective single center quality control study evaluating the appropriateness of IV iron replacement in 400 inpatients during 2019 and 2021 at a Swiss tertiary care hospital. Appropriateness of IV iron was assessed by expert chart review according to national and international guidelines.Results: IV iron prescriptions were assessed as inappropriate in 147 (37%) of cases (indication lacking in 13%, oral route preferred in 24%). Inappropriate prescribing was more common (p < .001) in surgical wards (66%) compared to medical units (48%) and the gynecologic ward (19%). Iron studies were lacking in 29% of inappropriate IV administrations. Insufficient replacement dosages were chosen in 38% of patients with appropriate prescription.Conclusion: Based on current guidelines, inappropriate in-hospital prescription of IV iron was frequently observed. Considerable differences exist between hospital units, which are consistent with conflicting recommendations of professional societies. We recommend increased attention toward the prescription quality to avoid unnecessary, expensive, and potentially harmful use of IV iron.
引用
收藏
页码:601 / 610
页数:10
相关论文
共 50 条
[41]   Preoperative intravenous iron to treat anaemia before major abdominal surgery (PREVENTT): a randomised, double-blind, controlled trial [J].
Richards, Toby ;
Baikady, Ravishankar Rao ;
Clevenger, Ben ;
Butcher, Anna ;
Abeysiri, Sandy ;
Chau, Marisa ;
Macdougall, Iain C. ;
Murphy, Gavin ;
Swinson, Rebecca ;
Collier, Tim ;
Van Dyck, Laura ;
Browne, John ;
Bradbury, Andrew ;
Dodd, Matthew ;
Evans, Richard ;
Brealey, David ;
Anker, Stefan D. ;
Klein, Andrew .
LANCET, 2020, 396 (10259) :1353-1361
[42]   Preoperative iron treatment in anaemic patients undergoing elective total hip or knee arthroplasty: a systematic review and meta-analysis [J].
Scrimshire, Ashley B. ;
Booth, Alison ;
Fairhurst, Caroline ;
Kotze, Alwyn ;
Reed, Mike ;
McDaid, Catriona .
BMJ OPEN, 2020, 10 (10)
[43]   Risk of Infection Associated With Administration of Intravenous Iron A Systematic Review and Meta-analysis [J].
Shah, Akshay A. ;
Donovan, Killian ;
Seeley, Claire ;
Dickson, Edward A. ;
Palmer, Antony J. R. ;
Doree, Carolyn ;
Brunskill, Susan ;
Reid, Jack ;
Acheson, Austin G. ;
Sugavanam, Anita ;
Litton, Edward ;
Stanworth, Simon J. .
JAMA NETWORK OPEN, 2021, 4 (11)
[44]  
Sibylle Twerenbold NS., 2022, HELSANA ARZNEIMITTEL
[45]  
Stoltzfus Rebecca J., 2003, Food and Nutrition Bulletin, V24, pS99
[46]  
Universitatsspital Basel, FRAUENKL
[47]   Acute heart failure and iron deficiency: a prospective, multicentre, observational study [J].
van Dalen, Dirk H. ;
Kragten, Johannes A. ;
Emans, Mireille E. ;
Van Ofwegen-Hanekamp, Clara E. E. ;
Klaarwater, Claudia C. R. ;
Spanjers, Mireille H. A. ;
Hendrick, Remond ;
van Deursen, Cees Th B. M. ;
Brunner-La Rocca, Hans-Peter .
ESC HEART FAILURE, 2022, 9 (01) :398-407
[48]   Osteomalacia as a Complication of Intravenous Iron Infusion: A Systematic Review of Case Reports [J].
Vilaca, Tatiane ;
Velmurugan, Nalini ;
Smith, Christopher ;
Abrahamsen, Bo ;
Eastell, Richard .
JOURNAL OF BONE AND MINERAL RESEARCH, 2022, 37 (06) :1188-1199
[49]   Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia Two Randomized Clinical Trials [J].
Wolf, Myles ;
Rubin, Janet ;
Achebe, Maureen ;
Econs, Michael J. ;
Peacock, Munro ;
Imel, Erik A. ;
Thomsen, Lars L. ;
Carpenter, Thomas O. ;
Weber, Thomas ;
Brandenburg, Vincent ;
Zoller, Heinz .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (05) :432-443
[50]   Randomized trial of intravenous iron-induced hypophosphatemia [J].
Wolf, Myles ;
Chertow, Glenn M. ;
Macdougall, Lain C. ;
Kaper, Robert ;
Krop, Julie ;
Strauss, William .
JCI INSIGHT, 2018, 3 (23)