Review on kidney diseases: types, treatment and potential of stem cell therapy

被引:2
作者
Singh, Jaspreet [1 ]
Singh, Sanjeev [1 ]
机构
[1] Lovely Profess Univ, Sch Bioengn & Biosci, 15935,Block 56,Room 202, Phagwara 144411, Punjab, India
关键词
Acute kidney injury; Chronic kidney diseases; Stem cells; Medicine for kidney diseases; GLOMERULAR-FILTRATION-RATE; HEMATOPOIETIC STEM; PROGENITOR CELLS; SURFACE-MARKERS; INJURY; GENERATION; ORGANOIDS; DIFFERENTIATION; TRANSPLANTATION; FAILURE;
D O I
10.1186/s41100-023-00475-2
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Renal disorders are an emerging global public health issue with a higher growth rate despite progress in supportive therapies. In order to find more promising treatments to stimulate renal repair, stem cell-based technology has been proposed as a potentially therapeutic option. The self-renewal and proliferative nature of stem cells raised the hope to fight against various diseases. Similarly, it opens a new path for the treatment and repair of damaged renal cells. This review focuses on the types of renal diseases; acute and chronic kidney disease-their statistical data, and the conventional drugs used for treatment. It includes the possible stem cell therapy mechanisms involved and outcomes recorded so far, the limitations of using these regenerative medicines, and the progressive improvement in stem cell therapy by adopting approaches like PiggyBac, Sleeping Beauty, and the Sendai virus. Specifically, about the paracrine activities of amniotic fluid stem cells, renal stem cells, embryonic stem cells, mesenchymal stem cell, induced pluripotent stem cells as well as other stem cells.
引用
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页数:12
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