Detection and management of HLA sensitization in candidates for adult heart transplantation

被引：14

作者：

DeFilippis, Ersilia M. ^{[1
]}

Kransdorf, Evan P. ^{[2
]}

Jaiswal, Abhishek ^{[3
]}

Zhang, Xiaohai ^{[4
]}

Patel, Jignesh ^{[2
]}

Kobashigawa, Jon A. ^{[2
]}

Baran, David A. ^{[5
]}

Kittleson, Michelle M. ^{[2
,6
]}

机构：

[1] Columbia Univ, Ctr Adv Cardiac Care, Div Cardiol, Irving Med Ctr, New York, NY USA

[2] Cedars Sinai Med Ctr, Smidt Heart Inst, Los Angeles, CA USA

[3] Hartford Hosp, Hartford HealthCare Heart & Vasc Inst, Hartford, CT USA

[4] Cedars Sinai Med Ctr, Comprehens Transplant Ctr, HLA & Immunogenet Lab, Los Angeles, CA USA

[5] Cleveland Clin, Heart Vasc & Thorac Inst, Weston, FL USA

[6] Cedars Sinai Med Ctr, Smidt Heart Inst, Div Cardiol ogy, 8670 Wilshire Blvd,2 Floor, Los Angeles, CA 90211 USA

来源：

JOURNAL OF HEART AND LUNG TRANSPLANTATION | 2023年 / 42卷 / 04期

关键词：

antibody; sensitization; heart transplantation; desensitization; ANTIBODY-MEDIATED REJECTION; MECHANICAL CIRCULATORY SUPPORT; CARDIAC ALLOGRAFT RECIPIENTS; ASSIST DEVICE RECIPIENTS; HUMAN-LEUKOCYTE ANTIGEN; CROSS-MATCH; INTRAVENOUS IMMUNOGLOBULIN; HETEROLOGOUS IMMUNITY; CLASS-I; THYRNOCYTE GLOBULIN;

D O I：

10.1016/j.healun.2022.12.019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heart transplantation (HT) remains the preferred therapy for patients with advanced heart failure. However, for sensitized HT candidates who have antibodies to human leukocyte antigens , finding a suitable donor can be challenging and can lead to adverse waitlist outcomes. In recent years, the number of sensitized patients awaiting HT has increased likely due to the use of durable and mechanical circulatory support as well as increasing number of candidates with underlying congenital heart disease. This State-of-the-Art review discusses the assessment of human leukocyte antigens antibodies, potential desensitization strategies including mechanisms of action and specific protocols, the approach to a potential donor including the use of complement-dependent cytotoxicity, flow cytometry, and virtual crossmatches, and peritransplant induction management.(c) 2022 International Society for Heart and Lung Transplantation. All rights reserved.

引用

页码：409 / 422

页数：14

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