Treatment Success Following Standard Antibiotic Treatment for Bacterial Vaginosis Is Not Associated With Pretreatment Genital Immune or Microbial Parameters

被引：7

作者：

Armstrong, Eric ^{[1
]}

Hemmerling, Anke ^{[2
]}

Joag, Vineet ^{[3
]}

Huibner, Sanja ^{[1
]}

Kulikova, Maria ^{[4
]}

Crawford, Emily ^{[5
]}

Castaneda, Gloria R. ^{[6
]}

Anzala, Omu ^{[7
]}

Obila, Onyango ^{[7
]}

Shahabi, Kamnoosh ^{[1
]}

Ravel, Jacques ^{[8
,9
]}

Coburn, Bryan ^{[1
,10
]}

Cohen, Craig R. ^{[2
]}

Kaul, Rupert ^{[1
,10
]}

机构：

[1] Univ Toronto, Dept Med, Toronto, ON, Canada

[2] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA 94143 USA

[3] Univ Minnesota, Dept Microbiol & Immunol, Minneapolis, MN USA

[4] Univ Hlth Network, Toronto Gen Hosp Res Inst, Toronto, ON, Canada

[5] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

[6] Chan Zuckerberg Biohub, San Francisco, CA USA

[7] Univ Nairobi, Dept Med Microbiol, Nairobi, Kenya

[8] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA

[9] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA

[10] Univ Hlth Network, Dept Med, Toronto, ON, Canada

来源：

OPEN FORUM INFECTIOUS DISEASES | 2023年 / 10卷 / 01期

基金：

加拿大健康研究院;

关键词：

HIV; antibiotics; bacterial vaginosis; immunology; mucosal immunology; vaginal microbiota; REAL-TIME PCR; TREATMENT FAILURE; RANDOMIZED-TRIAL; LACTIN-V; METRONIDAZOLE; RECURRENCE; THERAPY; ASSAY;

D O I：

10.1093/ofid/ofad007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. Bacterial vaginosis (BV) is a proinflammatory genital condition associated with adverse reproductive health outcomes, including increased HIV incidence. However, BV recurrence rates are high after standard antibiotic treatment. While the composition of the vaginal microbiota before BV treatment may be linked to BV recurrence, it is unclear whether the preceding genital immune milieu is predictive of treatment success. Methods. Here we assessed whether baseline vaginal soluble immune factors or the composition of the vaginal microbiota predicted treatment success 1 month after metronidazole treatment in 2 separate cohorts of women with BV, 1 in the United States and 1 in Kenya; samples within 48hours of BV treatment were also available for the US cohort. Results. Neither soluble immune factors nor the composition of the vaginal microbiota before BV treatment was associated with treatment response in either cohort. In the US cohort, although the absolute abundances of key vaginal bacterial taxa pretreatment were not associated with treatment response, participants with sustained BV clearance had a more pronounced reduction in the absolute abundance of Gardnerella vaginalis immediately after treatment. Conclusions. Pretreatment immune and microbial parameters were not predictive of BV treatment success in these clinical cohorts.

引用

页数：9

共 29 条

[1] Sustained effect of LACTIN-V (Lactobacillus crispatus CTV-05) on genital immunology following standard bacterial vaginosis treatment: results from a randomised, placebo-controlled trial [J].