Association between red blood cell distribution width-to-albumin ratio and the prognosis in patients with autoimmune encephalitis: a retrospective cohort study

被引:0
作者
Li, Dan [1 ]
Yang, Ali [1 ]
Xia, Mingrong [1 ]
Ma, Kai [1 ]
Zhang, Jiewen [1 ]
Guo, Yang [2 ]
Zang, Weizhou [1 ]
机构
[1] Zhengzhou Univ, Henan Univ, Dept Neurol, Henan Prov Peoples Hosp,Peoples Hosp, Zhengzhou, Peoples R China
[2] Zhengzhou Univ, Henan Univ, Henan Prov Peoples Hosp, Dept Neurosurg,Peoples Hosp, Zhengzhou, Peoples R China
来源
FRONTIERS IN NEUROLOGY | 2024年 / 14卷
关键词
RAR; autoimmune encephalitis; modified Rankin Scale; red blood cell distribution width; albumin; SEPSIS; RISK;
D O I
10.3389/fneur.2023.1276026
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
AimRed blood cell distribution width-to-albumin ratio (RAR) is a combined new indicator reflecting immunology and has been reported to predict the prognosis of inflammation-related diseases and brain diseases. However, the association and predictive value of RAR in the prognosis of patients with autoimmune encephalitis (AE) has not been reported.MethodsThis was a retrospective cohort study, and data were collected from the Henan Provincial People's Hospital. RAR was categorized according to quartile. The prognosis was assessed using the modified Rankin Scale (mRS), and an mRS score of >= 3 was defined as a poor prognosis. The logistical regression model was used to explore the association between RAR and the prognosis, with results reported as odds ratio (OR) and 95% confidence interval (CI). The predictive value of RAR was evaluated by calculating the area under the receiving operating curve (AUC), sensitivity, specificity, and accuracy.ResultsA total of 175 eligible patients were included for analysis, and 51 patients were identified as having poor prognosis. After adjusting age, cancer, other diseases, histological subtype, antiepileptic therapy, anti-tumor treatment, ICU treatment, and length of stay, RAR in the highest quartile (Q4) was found to be significantly associated with the high odds of poor prognosis (OR = 5.63, 95%CI: 1.98-16.02) compared to RAR in the lowest quartile (Q1). In addition, RAR was identified as a predictor for the prognosis of AE patients (AUC = 0.660, 95%CI: 0.574-0.746).ConclusionThis study found the close association and predictive value of RAR for the prognosis of AE patients, indicating that RAR might help clinicians identify high-risk populations.
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页数:11
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