The Multifaceted Role of Human Dickkopf-3 (DKK-3) in Development, Immune Modulation and Cancer

被引:5
|
作者
Mourtada, Jana [1 ,2 ]
Thibaudeau, Chloe [1 ,2 ]
Wasylyk, Bohdan [3 ,4 ,5 ,6 ]
Jung, Alain C. [1 ,2 ]
机构
[1] Inst Cancerol Strasbourg Europe, Lab Biol Tumorale, F-67200 Strasbourg, France
[2] Univ Strasbourg, Lab STREINTH Stress Response & Innovat Therapies, INSERM U1113 IRFAC, F-67200 Strasbourg, France
[3] Inst Genet & Biol Mol & Cellulaire IGBMC, F-67404 Illkirch Graffenstaden, France
[4] Inst Natl Sante & Rech Med INSERM, U1258, F-67404 Illkirch Graffenstaden, France
[5] Ctr Natl Rech Sci CNRS, UMR 7104, F-67404 Illkirch Graffenstaden, France
[6] Univ Strasbourg, F-67000 Strasbourg, France
关键词
Dickkopf (DKK) family; Wnt signaling pathway; DKK-3; development; immunomodulation; cancer; tumor suppressor; oncogene; therapy; SQUAMOUS-CELL CARCINOMA; SIGNALING PATHWAY; WNT; GENE; EXPRESSION; RECEPTOR; PROTEIN; KREMEN; HEAD; DIFFERENTIATION;
D O I
10.3390/cells13010075
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The human Dickkopf (DKK) family includes four main secreted proteins, DKK-1, DKK-2, DKK-3, and DKK-4, as well as the DKK-3 related protein soggy (Sgy-1 or DKKL1). These glycoproteins play crucial roles in various biological processes, and especially modulation of the Wnt signaling pathway. DKK-3 is distinct, with its multifaceted roles in development, stem cell differentiation and tissue homeostasis. Intriguingly, DKK-3 appears to have immunomodulatory functions and a complex role in cancer, acting as either a tumor suppressor or an oncogene, depending on the context. DKK-3 is a promising diagnostic and therapeutic target that can be modulated by epigenetic reactivation, gene therapy and DKK-3-blocking agents. However, further research is needed to optimize DKK-3-based therapies. In this review, we comprehensively describe the known functions of DKK-3 and highlight the importance of context in understanding and exploiting its roles in health and disease.
引用
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页数:14
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