Advances in the cellular biology, biochemistry, and molecular biology of acidocalcisomes

被引:9
作者
Docampo, Roberto [1 ]
机构
[1] Univ Georgia, Ctr Trop & Emerging Global Dis, Dept Cellular Biol, Athens, GA 30602 USA
关键词
acidocalcisome; blood clotting; calcium; dense granules; polyphosphate; VACUOLAR-H+-PYROPHOSPHATASE; PROTON-PUMPING PYROPHOSPHATASE; MAINTAINING FUNCTIONAL ACIDOCALCISOMES; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; PLASMA-MEMBRANE VESICLES; P-31; NMR-SPECTROSCOPY; TRYPANOSOMA-BRUCEI; TOXOPLASMA-GONDII; CONTRACTILE VACUOLE; CHLAMYDOMONAS-REINHARDTII;
D O I
10.1128/mmbr.00042-23
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Acidocalcisomes are organelles conserved during evolution and closely related to the so-called volutin granules of bacteria and archaea, to the acidocalcisome-like vacuoles of yeasts, and to the lysosome-related organelles of animal species. All these organelles have in common their acidity and high content of polyphosphate and calcium. They are characterized by a variety of functions from storage of phosphorus and calcium to roles in Ca2+ signaling, osmoregulation, blood coagulation, and inflammation. They interact with other organelles through membrane contact sites or by fusion, and have several enzymes, pumps, transporters, and channels.
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页数:36
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