The Effects of IL-23/IL-18-Polarized Neutrophils on Renal Ischemia-Reperfusion Injury and Allogeneic-Skin-Graft Rejection in Mice

被引：0

作者：

Wu, Changhong ^{[1
,2
]}

Xu, Jinglin ^{[1
,2
]}

Zhang, Zhaoqi ^{[3
]}

Wei, Dong ^{[3
]}

Xu, Yanan ^{[1
]}

Zhao, Yong ^{[1
,3
,4
]}

机构：

[1] Chinese Acad Sci, State Key Lab Membrane Biol, Inst Zool, Beijing 100101, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 101408, Peoples R China

[3] Chinese Acad Sci, Shenzhen Inst Synthet Biol, Shenzhen Inst Adv Technol, CAS Key Lab Quantitat Engn Biol, Shenzhen 518055, Peoples R China

[4] Shenzhen Inst Adv Technol, Fac Synthet Biol, Shenzhen 518055, Peoples R China

来源：

BIOMEDICINES | 2023年 / 11卷 / 12期

关键词：

neutrophils; ischemia-reperfusion injury; subsets; allogeneic transplantation; grafts; mice; DENDRITIC CELLS; DIFFERENTIATION; INTERLEUKIN-17A; INNATE; TUMOR; IL-17; BRONCHIOLITIS; PATHOGENESIS; RECRUITMENT; ACTIVATION;

D O I：

10.3390/biomedicines11123148

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neutrophils display heterogeneity and plasticity with different subgroups and immune-regulatory functions under various surrounding conditions. Neutrophils induced by IL-23/IL-18 (referred to N(IL-23+IL-18) neutrophils) have a unique gene-expression profile, with highly expressing IL-17, MHC-II, and costimulatory molecules. The adoptive transfer of N(IL-23+IL-18) neutrophils significantly increased the pathogenesis in a renal ischemia-reperfusion injury mouse model. N(IL-23+IL-18) neutrophils directly and efficiently induced allogeneic T cell proliferation in vitro. N(IL-23+IL-18) neutrophils enhanced the syngeneic T cell response to allogeneic antigens in mixed-lymphocyte reaction assays. The adoptive transfer of the donor or host N(IL-23+IL-18) neutrophils significantly enhanced the antidonor antibody production in an allogeneic-skin-transplanted mouse model, accompanied by increased Tfh cells in the spleens. Therefore, the neutrophil subset induced by IL-23/IL-18 promotes tissue injury and antidonor humoral response in the allogeneic transplantation mouse model.

引用

页数：20

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