Denosumab Use in Chronic Kidney Disease Associated Osteoporosis: A Narrative Review

被引：5

作者：

Abduelkarem, Abduelmula R. ^{[1
,2
,7
]}

Guella, Adnane ^{[3
]}

Hamrouni, Amar M. ^{[4
]}

Hassanein, Mohammed M. ^{[1
]}

Nasr, Ahmed ^{[5
]}

Rana, Owais ^{[6
]}

机构：

[1] Univ Sharjah, Coll Pharm, Dept Pharm Practice & Pharmacotherapeut, Sharjah, U Arab Emirates

[2] Univ Sharjah, Res Inst Med & Hlth Sci, Sharjah, U Arab Emirates

[3] Univ Hosp Sharjah, Dept Nephrol, Sharjah, U Arab Emirates

[4] Al Ain Univ, Dept Pharmaceut Sci, Coll Pharm, Al Ain, U Arab Emirates

[5] Univ Hosp Sharjah, Pharm Dept, Sharjah, U Arab Emirates

[6] Univ Hosp Sharjah, Dept Internal Med, Sharjah, U Arab Emirates

[7] Univ Sharjah, Coll Pharm, Dept Pharm Practice & Pharmacotherapeut, Univ City Rd, POB 27272, Sharjah, U Arab Emirates

来源：

INFECTION AND DRUG RESISTANCE | 2023年 / 16卷

关键词：

denosumab; chronic kidney disease; hemodialysis; bone disease; fracture risk reduction; BONE-MINERAL DENSITY; POSTMENOPAUSAL WOMEN; CKD-MBD; MANAGEMENT; FRACTURES; EFFICACY; SAFETY; HYPOCALCEMIA; PREVENTION; ACID;

D O I：

10.2147/RMHP.S426869

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Chronic kidney disease (CKD) and hemodialysis (HD) patients have a high incidence of bone disease and increased fracture risk, making effective management of their bone health a clinical challenge. Denosumab, a human monoclonal antibody, has been investigated as a therapeutic option in this patient population. In this review, we summarize the current evidence on the efficacy and safety of denosumab in CKD and HD patients. A comprehensive search of the relevant literature was conducted, including randomized controlled trials, observational studies, and meta-analyses. The findings suggest that denosumab reduces the risk of fractures and improves bone mineral density in all stages of CKD. The results of this review support the use of denosumab as a promising option for managing bone disease in CKD and HD patients.

引用

页码：1809 / 1813

页数：5

共 41 条

[1] Efficacy and safety of ibandronate given by intravenous injection once every 3 months [J].

Adami, S ;

Felsenberg, D ;

Christiansen, C ;

Robinson, J ;

Lorenc, RS ;

Mahoney, P ;

Coutant, K ;

Schimmer, RC ;

Delmas, R .

BONE, 2004, 34 (05) :881-889

[2] A single-dose study of denosumab in patients with various degrees of renal impairment [J].

Block, Geoffrey A. ;

Bone, Henry G. ;

Fang, Liang ;

Lee, Edward ;

Padhi, Desmond .

JOURNAL OF BONE AND MINERAL RESEARCH, 2012, 27 (07) :1471-1479

[3] Effect of Twice-Yearly Denosumab on Prevention of Bone Mineral Density Loss in De Novo Kidney Transplant Recipients: A Randomized Controlled Trial [J].

Bonani, M. ;

Frey, D. ;

Brockmann, J. ;

Fehr, T. ;

Mueller, T. F. ;

Saleh, L. ;

von Eckardstein, A. ;

Graf, N. ;

Wuehrich, R. P. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2016, 16 (06) :1882-1891

[4] Osteoporosis, bone mineral density and CKD-MBD: treatment considerations [J].

Bover, Jordi ;

Bailone, Lucia ;

Lopez-Baez, Victor ;

Benito, Silvia ;

Ciceri, Paola ;

Galassi, Andrea ;

Cozzolino, Mario .

JOURNAL OF NEPHROLOGY, 2017, 30 (05) :677-687

[5] Osteoclast differentiation and activation [J].

Boyle, WJ ;

Simonet, WS ;

Lacey, DL .

NATURE, 2003, 423 (6937) :337-342

[6] Denosumab Safety and Efficacy Among Participants in the FREEDOM Extension Study With Mild to Moderate Chronic Kidney Disease [J].

Broadwell, Aaron ;

Chines, Arkadi ;

Ebeling, Peter R. ;

Franek, Edward ;

Huang, Shuang ;

Smith, Shawna ;

Kendler, David ;

Messina, Osvaldo ;

Miller, Paul D. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2021, 106 (02) :397-409

[7] Efficacy of Osteoporosis Medications for Patients With Chronic Kidney Disease: An Updated Systematic Review and Network Meta-Analysis [J].

Chen, Chia-Hsien ;

Lo, Wei-Cheng ;

Hu, Ping-Jen ;

Chan, Hsiu-Chen ;

Shen, Wan-Chen ;

Wu, Mai-Szu ;

Wu, Mei-Yi .

FRONTIERS IN PHARMACOLOGY, 2022, 13

[8] Effects of Denosumab and Calcitriol on Severe Secondary Hyperparathyroidism in Dialysis Patients With Low Bone Mass [J].

Chen, Chien-Liang ;

Chen, Nai-Ching ;

Liang, Huei-Lung ;

Hsu, Chih-Yang ;

Chou, Kang-Ju ;

Fang, Hua-Chang ;

Lee, Po-Tsang .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2015, 100 (07) :2784-2792

[9] Denosumab-Induced Hypocalcemia and Hyperparathyroidism in de novo Kidney Transplant Recipients [J].

Cianciolo, Giuseppe ;

Tondolo, Francesco ;

Barbuto, Simona ;

Iacovella, Francesca ;

Zavatta, Guido ;

Altieri, Paola ;

Grandinetti, Valeria ;

Comai, Giorgia ;

Cozzolino, Mario ;

La Manna, Gaetano .

AMERICAN JOURNAL OF NEPHROLOGY, 2021, 52 (08) :611-619

[10] Severe hypocalcaemia following denosumab and iron infusion [J].

Cohen, Adrienne ;

Chacko, Bobby .

NEPHROLOGY, 2022, 27 (09) :781-782

← 1 2 3 4 5 →