Applications of virus-specific T cell therapies post-BMT

被引：19

作者：

Motta, Cecilia M. ^{[1
]}

Keller, Michael D. ^{[1
,2
,3
]}

Bollard, Catherine M. ^{[1
,3
,4
]}

机构：

[1] Childrens Natl Hosp, Ctr Canc & Immunol Res, 111 Michigan Ave NW, Washington, DC 20010 USA

[2] Childrens Natl Hosp, Div Allergy & Immunol, Washington, DC 20010 USA

[3] George Washington Univ, GW Canc Ctr, Washington, DC USA

[4] Childrens Natl Hosp, Div Blood & Marrow Transplantat, Washington, DC 20010 USA

来源：

SEMINARS IN HEMATOLOGY | 2023年 / 60卷 / 01期

关键词：

Virus -specific T cells; Immunotherapy; Adoptive transfer; Viruses; EPSTEIN-BARR-VIRUS; REFRACTORY VIRAL-INFECTIONS; BK VIRUS; LYMPHOPROLIFERATIVE DISEASE; CROSS-REACTIVITY; ADOPTIVE IMMUNOTHERAPY; CYTOKINE COMBINATIONS; ADENOVIRUS INFECTION; IMMUNE-RESPONSE; BONE-MARROW;

D O I：

10.1053/j.seminhematol.2022.12.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hematopoietic stem cell transplantation (HSCT) has been used as a curative standard of care for moder-ate to severe primary immunodeficiency disorders as well as relapsed hematologic malignancies for over 50 years [ 1 , 2 ]. However, chronic and refractory viral infections remain a leading cause of morbidity and mortality in the immune deficient period following HSCT, where use of available antiviral pharmacother-apies is limited by toxicity and emerging resistance [ 3 ]. Adoptive immunotherapy using virus-specific T cells (VSTs) has been explored for over 2 decades [ 4 , 5 ] in patients post-HSCT and has been shown prior phase I-II studies to be safe and effective for treatment or preventions of viral infections including cy-tomegalovirus, Epstein-Barr virus, BK virus, and adenovirus with minimal toxicity and low risk of graft vs host disease [ 6 -9 ]. This review summarizes methodologies to generate VSTs the clinical results utilizing VST therapeutics and the challenges and future directions for the field.(c) 2022 Published by Elsevier Inc.

引用

页码：10 / 19

页数：10

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