Nonalcoholic fatty liver disease in adolescents with phenylketonuria

被引:0
作者
Silveira, Adriana Marcia [1 ,2 ,3 ,8 ]
Lima, Poliane Lopes [3 ]
Alves, Michelle Rosa Andrade [4 ]
de Jesus, Rosangela Passos [5 ]
Pinto-Silva, Rogerio Augusto [6 ]
Rodrigues, Valeria de Melo [1 ]
Starling, Ana Lucia Pimenta [1 ]
Norton, Rocksane de Carvalho [7 ]
de Aguiar, Marcos Jose Burle [1 ]
机构
[1] Univ Fed Minas Gerais UFMG, Fac Med, Dept Pediat, Belo Horizonte, MG, Brazil
[2] Programa Posgrad Ciencias Saude, Saude Crianca & Adolescente, Belo Horizonte, MG, Brazil
[3] Fac Minas FAMINAS BH, Dept Nutr, Belo Horizonte, MG, Brazil
[4] Pontificia Univ Catolica Minas Gerais PUC Minas, Belo Horizonte, MG, Brazil
[5] Univ Fed Bahia UFBA, Dept Nutr, Salvador, BA, Brazil
[6] Clin CEU Diagnost, Belo Horizonte, MG, Brazil
[7] Univ Fed Minas Gerais UFMG, Fac Med, Dept Pediat, Nucleo Acoes & Pesquisa Apoio Diagnost NUPAD, Belo Horizonte, MG, Brazil
[8] Univ Fed Minas Gerais UFMG, Fac Med, Belo Horizonte, MG, Brazil
关键词
Non-alcoholic fatty liver disease; Inborn errors of metabolism; Diet therapy; Body mass index; Adolescents; HEPATIC STEATOSIS; OBESE CHILDREN; PARAMETERS; STEATOHEPATITIS; EPIDEMIOLOGY; PREVALENCE; OVERWEIGHT;
D O I
10.1016/j.jped.2022.08.003
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective: This study aimed to investigate non-alcoholic fatty liver disease (NAFLD) occurrence and factors associated with the disease in phenylketonuria (PKU) patients undergoing exclusive dietary treatment.Method: This cross-sectional study included 101 adolescents 10 to < 20 years of age with PKU, who were undergoing exclusive dietary treatment and monitored since early diagnosis at a single reference service. Anthropometric and biochemical assessments were performed and food intake was documented, and an ultrasound diagnosis of NAFLD was established. Data were evalu-ated using the Student's t-test for continuous variables, the chi-square for categorical variables, and logistic regression using the Wald chi-squared test; differences with p < 0.05 were consid-ered to be statistically significant.Results: NAFLD was detected in 26 (25.7%) teenagers. There was no difference in prevalence between the sexes or nutritional status. The final logistic regression model revealed low sensitiv-ity (26.1%) and high specificity (94.7%). The specificity suggested a lower likelihood of NAFLD in older adolescents, in the presence of normal or high levels of alkaline phosphatase, lower carbo-hydrate intake, and adequate protein and lipid intake.Conclusions: The prevalence of NAFLD in adolescents with PKU was higher than that found in healthy Brazilian adolescents and similar to that found in obese Brazilian children, suggesting a higher risk for NAFLD in patients with PKU treated exclusively by dietary modification.(c) 2022 Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Pediatria. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/ by-nc-nd/4.0/).
引用
收藏
页码:174 / 180
页数:7
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