Transcranial cortico-cortical paired associative stimulation (ccPAS) over ventral premotor-motor pathways enhances action performance and corticomotor excitability in young adults more than in elderly adults

被引:26
作者
Turrini, Sonia [1 ,2 ]
Bevacqua, Naomi [1 ,3 ]
Cataneo, Antonio [1 ]
Chiappini, Emilio [1 ,4 ]
Fiori, Francesca [1 ,5 ]
Candidi, Matteo [3 ]
Avenanti, Alessio [1 ,6 ]
机构
[1] Alma Mater Studiorum Univ Bologna, Ctr Studi & Ric Neurosci Cognit, Dipartimento Psicol, Cesena, Italy
[2] Harvard Med Sch, Massachusetts Gen Hosp, Gordon Ctr Med Imaging, Precis Neurosci & Neuromodulat Program, Boston, MA 02115 USA
[3] Sapienza Univ Roma, Dipartimento Psicol, Rome, Italy
[4] Univ Vienna, Dept Clin & Hlth Psychol, Vienna, Austria
[5] Unita Ric Neurofisiol & Neuroingn Interaz Uomo Tec, Dipartimento Med, Rome, Italy
[6] Univ Catolica Maule, Ctr Invest Neuropsicol & Neurociencias Cognit, Talca, Chile
关键词
TMS; ccPAS; Hebbian plasticity; manual dexterity; aging; motor system; TIMING-DEPENDENT PLASTICITY; PEG TEST; CORTEX; BRAIN; CONNECTIVITY; RTMS; TMS; INDUCTION; ACCURACY; HUMANS;
D O I
10.3389/fnagi.2023.1119508
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Transcranial magnetic stimulation (TMS) methods such as cortico-cortical paired associative stimulation (ccPAS) can increase the strength of functional connectivity between ventral premotor cortex (PMv) and primary motor cortex (M1) via spike timing-dependent plasticity (STDP), leading to enhanced motor functions in young adults. However, whether this STDP-inducing protocol is effective in the aging brain remains unclear. In two groups of young and elderly healthy adults, we evaluated manual dexterity with the 9-hole peg task before and after ccPAS of the left PMv-M1 circuit. We observed that ccPAS enhanced dexterity in young adults, and this effect was anticipated by a progressive increase in motor-evoked potentials (MEPs) during ccPAS administration. No similar effects were observed in elderly individuals or in a control task. Across age groups, we observed that the magnitude of MEP changes predicted larger behavioral improvements. These findings demonstrate that left PMv-to-M1 ccPAS induces functionally specific improvements in young adults' manual dexterity and an increase in corticomotor excitability, but altered plasticity prevents the effectiveness of ccPAS in the elderly.
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页数:8
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