Combined treatments with AZD5363, AZD8542, curcumin or resveratrol induce death of human glioblastoma cells by suppressing the PI3K/AKT and SHH signaling pathways

被引：7

作者：

Mejia-Rodriguez, Rosalinda ^{[1
]}

Romero-Trejo, Daniel ^{[1
]}

Gonzalez, Rosa O. ^{[2
]}

Segovia, Jose ^{[1
]}

机构：

[1] Ctr Invest & Estudios Avanzados IPN, Dept Fisiol Biofis & Neurociencias, Av IPN 2508, Mexico City 07300, DF, Mexico

[2] Univ Autonoma Metropolitana Iztapalapa UAM I, Dept Matemat, Mexico City, DF, Mexico

来源：

BIOCHEMISTRY AND BIOPHYSICS REPORTS | 2023年 / 33卷

基金：

芬兰科学院;

关键词：

Glioma; Combined therapy; Resveratrol; Curcumin; AZD5363; AZD8542; ORAL BIOAVAILABILITY; ANTITUMOR-ACTIVITY; CYCLE PROGRESSION; MALIGNANT GLIOMA; SOLUBLE FORMS; TUMOR-CELLS; AKT KINASES; STEM-CELLS; IN-VITRO; CANCER;

D O I：

10.1016/j.bbrep.2023.101430

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glioblastoma (GBM) is a very aggressive tumor that presents vascularization, necrosis and is resistant to chemotherapy and radiotherapy. Current treatments are not effective eradicating GBM, thus, there is an urgent need to develop novel therapeutic strategies against GBM. AZD5363, AZD8542, curcumin and resveratrol, are widely studied for the treatment of cancer and in the present study we explored the effects of the administration of combined treatments with AZD5363, AZD8542, curcumin or resveratrol on human GBM cells. We found that the combined treatments with AZD5363+AZD8542+Curcumin and AZD8542+Curcumin+Resveratrol inhibit the PI3K/AKT and SHH survival pathways by decreasing the activity of AKT, the reduction of the expression of SMO, pP70S6k, pS6k, GLI1, p21 and p27, and the activation of caspase-3 as a marker of apoptosis. These results provide evidence that the combined treatments AZD5363+AZD8542+Curcumin and AZD8542+Curcumin+Resveratrol have the potential to be an interesting option against GBM.

引用

页数：12