Two new sesquiterpene derivatives, dendocarbin B and bisaborosaol C with antifungal activity from the endophytic fungus Nigrospora chinensis GGY-3

被引：2

作者：

Wang, Biao ^{[1
,2
]}

Li, Hao ^{[1
,2
]}

Chen, Tianyu ^{[1
,2
]}

Wei, Wei ^{[3
]}

Liu, Guiyou ^{[3
]}

Huang, Weiqing ^{[1
,2
]}

He, Bo ^{[1
,2
]}

Ye, Yonghao ^{[1
,2
,4
]}

Yan, Wei ^{[1
,2
,4
]}

机构：

[1] Nanjing Agr Univ, Coll Plant Protect, State & Local Joint Engn Res Ctr Green Pesticide I, Nanjing, Peoples R China

[2] Minist Educ, Key Lab Integrated Management Crop Dis & Pests, Nanjing, Peoples R China

[3] Jiangsu Second Normal Univ, Sch Life Sci & Chem Engn, Nanjing, Peoples R China

[4] Sanya Inst Nanjing Agr Univ, Sanya, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2024年 / 38卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Endophytic fungus; sesquiterpene derivative; anti-fungal activity; anti-bacterial activity; antioxidant activity; SECONDARY METABOLITES; DIVERSITY; BIOSYNTHESIS; PATHWAY;

D O I：

10.1080/14786419.2022.2151011

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two novel sesquiterpene derivatives, dendocarbin B (1), bisaborosaol C (2), and nine known compounds (3-11), were isolated from Nigrospora chinensis GGY-3 derived from Ilex cornuta. The structures of new compounds were elucidated using HR-ESI-MS, 1 D and 2 D NMR spectra, X-ray diffraction analysis as well as ECD calculation and comparison. Compound 1 showed moderate antifungal activities against Rhizoctonia solani and Botrytis cinerea. Compounds 5 and 6 exhibited significant inhibitory activity against Phytophthora capsici, Magnaporthe oryzae and R. solani with EC50 values ranging from 13.91 to 29.49 mu g/mL. Compounds 10 and 11 displayed moderate antibacterial effects on Bacillus subtilis and Xanthomonas oryzae pv. oryzae (Xoo), with MIC values of 16-64 mu g/mL. Particularly, 11 presented strong antibacterial activity against Staphylococcus aureus with an MIC value of 4 mu g/mL (2 mu g/mL for streptomycin sulfate). In addition, compound 11 also possessed DPPH radical scavenging capability with an IC50 value of 14.80 mu g/mL.

引用

页码：1478 / 1486

页数：9

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