Garcimckeans A-C, three new xanthones from the stems of Garcinia mckeaniana, and their cytotoxic activity

被引：7

作者：

Nguyen Thi Thu Ha ^{[1
,2
]}

Nguyen Van Tuyen ^{[1
,2
]}

Nguyen Thanh Tra ^{[1
,2
]}

Le Thi Tu Anh ^{[1
]}

Ninh The Son ^{[1
]}

Mac Litaudon ^{[3
]}

Pham Van Cuong ^{[2
,4
]}

Bui Huu Tai ^{[2
,4
]}

Phan Van Kiem ^{[2
,4
]}

机构：

[1] Vietnam Acad Sci & Technol, Inst Chem, Hanoi, Vietnam

[2] Vietnam Acad Sci & Technol, Grad Univ Sci & Technol, Hanoi, Vietnam

[3] Univ Paris Sud, Inst Chem Nat Subst, CNRS ICSN, UPR 2301, Gif Sur Yvette, France

[4] Vietnam Acad Sci & Technol, Inst Marine Biochem, Hanoi, Vietnam

来源：

NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 01期

关键词：

Clusiaceae; Garcinia mckeaniana; garcimckean; xanthones; cytotoxic activity; MANGOSTANA PERICARPS; PRENYLATED XANTHONES; GROWTH; FRUIT;

D O I：

10.1080/14786419.2021.1950717

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Three new xanthones, garcimckeans A-C (1-3) were isolated from the methanol extract of the stems of Garcinia mckeaniana (Clusiaceae). Their structures were established by extensive spectroscopic analysis (HR-ESI-MS and 1 D and 2 D NMR) and by comparison of the spectral data with those reported in the literature. Compounds 1-3 displayed weak cytotoxic activity toward KB, Lu, HepG2, and MCF7 cell lines using the MTT assay with IC50 values ranging from 71.03 +/- 2.93 to 90.40 +/- 7.13 mu M compared to that of the positive control compound, ellipticine (IC50: 1.22 +/- 0.10 similar to 2.44 +/- 0.2 mu M).

引用

页码：77 / 84

页数：8

共 23 条

[1] Chemistry and Biology of the Caged Garcinia Xanthones [J].

Chantarasriwong, Oraphin ;

Batova, Ayse ;

Chavasiri, Warinthorn ;

Theodorakis, Emmanuel A. .

CHEMISTRY-A EUROPEAN JOURNAL, 2010, 16 (33) :9944-9962

[2] Identification and evaluation of apoptotic compounds from Garcinia oligantha [J].

Gao, Xue-Mei ;

Yu, Ting ;

Cui, Ming-zhu ;

Pu, Jian-Xin ;

Du, Xue ;

Han, Quan-bin ;

Hu, Qiu-fen ;

Liu, Tian-Cheng ;

Luo, Kathy Qian ;

Xu, Hong-Xi .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (06) :2350-2353

[3]

Ha N.T.T., 2020, Vietnam J. Sci. Technol, V58, P411, DOI [10.15625/2525-2518/58/4/14680, DOI 10.15625/2525-2518/58/4/14680]

[4] Cytotoxic Xanthone Constituents of the Stem Bark of Garcinia mangostana (Mangosteen) [J].

Han, Ah-Reum ;

Kim, Jeong-Ah ;

Lantvit, Daniel D. ;

Leonardus, B. S. Kardono ;

Riswan, Soedarsono ;

Chai, Heebyung ;

de Blanco, Esperanza J. Carcache ;

Farnsworth, Norman R. ;

Swanson, Steven M. ;

Kinghorn, A. Douglas .

JOURNAL OF NATURAL PRODUCTS, 2009, 72 (11) :2028-2031

[5] Xanthones with growth inhibition against HeLa cells from Garcinia xipshuanbannaensis [J].

Han, Quan-Bin ;

Yang, Nian-Yun ;

Tian, Hong-Lei ;

Qiao, Chun-Feng ;

Song, Jing-Zheng ;

Chang, Donald C. ;

Chen, Shi-Lin ;

Luo, Kathy Q. ;

Xu, Hong-Xi .

PHYTOCHEMISTRY, 2008, 69 (11) :2187-2192

[6] An overview on genus garcinia: phytochemical and therapeutical aspects [J].

Hemshekhar, M. ;

Sunitha, K. ;

Santhosh, M. Sebastin ;

Devaraja, S. ;

Kemparaju, K. ;

Vishwanath, B. S. ;

Niranjana, S. R. ;

Girish, K. S. .

PHYTOCHEMISTRY REVIEWS, 2011, 10 (03) :325-351

[7]

Ho PH., 1999, FLORA OF VIETNAM, V1

[8] Mangostanaxanthone VIIII, a new xanthone from Garcinia mangostana pericarps, α-amylase inhibitory activity, and molecular docking studies [J].

Ibrahim, Sabrin R. M. ;

Mohamed, Gamal A. ;

Khayat, Maan T. ;

Ahmed, Sahar ;

Abo-Haded, Hany ;

Alshali, Khalid Z. .

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 2019, 29 (02) :206-212

[9] Mangostanaxanthone VIII, a new xanthone from Garcinia mangostana and its cytotoxic activity [J].

Ibrahim, Sabrin R. M. ;

Abdallah, Hossam M. ;

El-Halawany, Ali M. ;

Nafady, Alaa M. ;

Mohamed, Gamal A. .

NATURAL PRODUCT RESEARCH, 2019, 33 (02) :258-265

[10] Garcixanthones B and C, new xanthones from the pericarps of Garcinia mangostana and their cytotoxic activity [J].

Ibrahim, Sabrin R. M. ;

Abdallah, Hossam M. ;

El-Halawany, Ali M. ;

Radwan, Mohammed F. ;

Shehata, Ibrahim A. ;

Al-Harshany, Essam M. ;

Zayed, Mohamed F. ;

Mohamed, Gamal A. .

PHYTOCHEMISTRY LETTERS, 2018, 25 :12-16

← 1 2 3 →