In-vitro and in-vivo bio-corrosion and biocompatibility responses of bioactive TiTaNb films with various Ta contents on Ti6Al4V implants

被引：6

作者：

Chen, Y. H. ^{[1
]}

Chen, W. Y. ^{[1
]}

Lin, Y. S. ^{[2
,3
]}

Chen, C. H. ^{[2
,3
,7
]}

Zhou, Rui ^{[1
]}

Chou, T. H. ^{[1
]}

Zhu, Y. T. ^{[1
,6
]}

Li, W. P. ^{[1
]}

Wang, X. ^{[4
]}

Chen, S. C. ^{[5
]}

Chen, C. Y. ^{[5
]}

Huang, J. C. ^{[1
,5
]}

机构：

[1] City Univ Hong Kong, Hong Kong Inst Adv Study, Dept Mat Sci & Engn, Kowloon, Hong Kong, Peoples R China

[2] Kaohsiung Med Univ, Orthoped Res Ctr, Dept Orthoped, Kaohsiung 807, Taiwan

[3] Kaohsiung Med Univ, Kaohsiung Municipal Ta Tung Hosp, Regenerat Med & Cell Therapy Res Ctr, Dept Orthoped, Kaohsiung, Taiwan

[4] Liaoning Shihua Univ, Sch Mech Engn, Fushun 113001, Peoples R China

[5] Natl Sun Yat Sen Univ, Dept Mat & Optoelect Sci, Kaohsiung 804, Taiwan

[6] City Univ Hong Kong, Mech Behav Div Shenyang Natl Lab Mat Sci, Kowloon, Hong Kong, Peoples R China

[7] Kaohsiung Med Univ, Kaohsiung Municipal Ta Tung Hosp, Dept Orthoped, Kaohsiung, Taiwan

来源：

JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T | 2023年 / 25卷

关键词：

TiTaNb; Sputtering; Bioactive thin film; Surface modification; Biological corrosion; Osteointegration; LAYER FORMATION; ALLOY; TANTALUM; BETA; OSSEOINTEGRATION; RESISTANCE; COATINGS; CELLS; TI-6AL-4V; KINETICS;

D O I：

10.1016/j.jmrt.2023.06.216

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Despite the widespread use of Ti6Al4V in orthopedics, the health concerns, innate bio-inert property and the pursuit of long-term implantation in the body limit its development. For these reasons, we intend to modify the chemical and physical properties of Ti6Al4V by the sputtered bioactive Ti-Ta-Nb films. All these elements exhibit great biocompatibility in human body and the Ti-Ta-Nb system can form more stable passive layer to prevent the corrosion. In this study, we evaluate the effectiveness of the surface modification for Ti-Ta -Nb system on Ti6Al4V and investigate the influence of bioactive element Ta content from 25, 33, to 50 at% by the bio-corrosion behavior, passivation, in-vitro biological analysis and invivo implantation. The results show the Ti-Ta-Nb system has higher corrosion resistance and better biological properties than Ti6Al4V. Furthermore, following the electrochemical tests and passive layer observation, with increasing Ta content in Ti-Ta-Nb system, the corrosion resistance increases. The in-vitro measurements demonstrate that the higher Ta content in this system would lead to favorable surface condition for cell viability, proliferation, differentiation and adhesion. As for the in-vivo response upon implantation, the Ta50 film demonstrates significantly greater osteointegration capability. In summary, the current results reveal that the Ti-Ta-Nb system could greatly promote the surface properties of Ti6Al4V, and Ta50 is demonstrated to be a more promising coating choice for orthopedic

引用

页码：3803 / 3818

页数：16

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