Metabolites isolated from the mangrove endophytic fungus Didymella sp. CYSK-4 and their cytotoxic activities

被引：4
作者：
Yuan, Yilin [1 ]
Wang, Guisheng [1 ,2 ]
She, Zhigang [2 ]
Chen, Yan [1 ,3 ]
Kang, Wenyi [1 ]
机构：
[1] Henan Univ, Natl R&D Ctr Edible Fungus Proc Technol, Kaifeng 475004, Peoples R China
[2] Sun Yat Sen Univ, Sch Chem, Guangzhou 510275, Peoples R China
[3] Anhui Med Univ, Sch Pharm, Hefei 230032, Peoples R China
来源：
FITOTERAPIA | 2023年 / 171卷
关键词：
Mangrove endophytic fungus; Didymella sp; Cytotoxicity; ALKALOIDS;
D O I：
10.1016/j.fitote.2023.105692
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new 12- or 13- membered-ring macrocyclic alkaloids ascomylactam D and E (1 & 2), and a pair of new enantiomer (+)- and (-)- didymetone (3) were purified from the mangrove endophytic fungus Didymella sp. CYSK-4. Their structures and absolute configurations were determined by extensive spectroscopic analysis, single-crystal X-ray diffraction, ECD and C-13 NMR calculations. Compound 2 exhibited significant cytotoxicity against human A549 and KYSE 150 cancer cell lines with IC50 values of 2.8 mu M and 5.9 mu M, respectively.
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页数：6
相关论文
共 21 条
[1]   Didymellanosine, a new decahydrofluorene analogue, and ascolactone C from Didymella sp. IEA-3B.1, an endophyte of Terminalia catappa [J].
Ariantari, Ni P. ;
Ancheeva, Elena ;
Frank, Marian ;
Stuhldreier, Fabian ;
Meier, Dieter ;
Groener, Yvonne ;
Reimche, Irene ;
Teusch, Nicole ;
Wesselborg, Sebastian ;
Mueller, Werner E. G. ;
Kalscheuer, Rainer ;
Liu, Zhen ;
Proksch, Peter .
RSC ADVANCES, 2020, 10 (12) :7232-7240
[2]   Secondary metabolites from mangrove-associated fungi: source, chemistry and bioactivities [J].
Chen, Senhua ;
Cai, Runlin ;
Liu, Zhaoming ;
Cui, Hui ;
She, Zhigang .
NATURAL PRODUCT REPORTS, 2022, 39 (03) :560-595
[3]   Cytotoxic Bromine- and Iodine-Containing Cytochalasins Produced by the Mangrove Endophytic Fungus Phomopsis sp. QYM-13 Using the OSMAC Approach [J].
Chen, Yan ;
Yang, Wencong ;
Zou, Ge ;
Wang, Guisheng ;
Kang, Wenyi ;
Yuan, Jie ;
She, Zhigang .
JOURNAL OF NATURAL PRODUCTS, 2022, 85 (05) :1229-1238
[4]   Metabolites With Cytotoxic Activities From the Mangrove Endophytic Fungus Fusarium sp. 2ST2 [J].
Chen, Yan ;
Wang, Guisheng ;
Yuan, Yilin ;
Zou, Ge ;
Yang, Wencong ;
Tan, Qi ;
Kang, Wenyi ;
She, Zhigang .
FRONTIERS IN CHEMISTRY, 2022, 10
[5]   Bioactive sesquiterpene derivatives from mangrove endophytic fungus Phomopsis sp. SYSU-QYP-23: Structures and nitric oxide inhibitory activities [J].
Chen, Yan ;
Liu, Hongju ;
Zou, Ge ;
Yang, Wencong ;
Zhang, Lishan ;
Yan, Zhangyuan ;
Long, Yuhua ;
She, Zhigang .
BIOORGANIC CHEMISTRY, 2021, 107
[6]   Metabolites with Anti-Inflammatory Activity from the Mangrove Endophytic Fungus Diaporthe sp. QYM12 [J].
Chen, Yan ;
Zou, Ge ;
Yang, Wencong ;
Zhao, Yingying ;
Tan, Qi ;
Chen, Lin ;
Wang, Jinmei ;
Ma, Changyang ;
Kang, Wenyi ;
She, Zhigang .
MARINE DRUGS, 2021, 19 (02)
[7]   Anti-inflammatory activities of alkaloids from the mangrove endophytic fungus Phomopsis sp. SYSUQYP-23 [J].
Chen, Yan ;
Zhang, Lishan ;
Zou, Ge ;
Li, Changqun ;
Yang, Wencong ;
Liu, Hongju ;
She, Zhigang .
BIOORGANIC CHEMISTRY, 2020, 97
[8]   Ascomylactams A-C, Cytotoxic 12-or 13-Membered-Ring Macrocyclic Alkaloids Isolated from the Mangrove Endophytic Fungus Didymella sp. CYSK-4, and Structure Revisions of Phomapyrrolidones A and C [J].
Chen, Yan ;
Liu, Zhaoming ;
Huang, Yun ;
Liu, Lan ;
He, Jianguo ;
Wang, Lan ;
Yuan, Jie ;
She, Zhigang .
JOURNAL OF NATURAL PRODUCTS, 2019, 82 (07) :1752-1758
[9]   Embellicines A and B: Absolute Configuration and NF-κB Transcriptional Inhibitory Activity [J].
Ebrahim, Weaam ;
Aly, Amal H. ;
Wray, Victor ;
Mandi, Attila ;
Teiten, Marie-Helene ;
Gaascht, Francois ;
Orlikova, Barbora ;
Kassack, Matthias U. ;
Lin, WenHan ;
Diederich, Marc ;
Kurtan, Tibor ;
Debbab, Abdessamad ;
Proksch, Peter .
JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (07) :2991-2999
[10]  
Frisch MJ., 2016, Gaussian 16 Rev. C.01
123