Long-term Risk of Epilepsy Following Invasive Group B Streptococcus Disease in Neonates in Denmark

被引:5
作者
Lykke, Malene Risager [1 ,2 ]
Sorensen, Henrik Toft [1 ,2 ]
Lawn, Joy Elisabeth [3 ,4 ]
Horvath-Puho, Erzsebet [1 ,2 ]
机构
[1] Aarhus Univ, Dept Clin Epidemiol, Aarhus, Denmark
[2] Aarhus Univ Hosp, Olof Palmes Alle 43-45, DK-8200 Aarhus N, Denmark
[3] London Sch Hyg & Trop Med, Fac Epidemiol & Populat Hlth, London, England
[4] London Sch Hyg & Trop Med, Maternal Adolescent Reprod & Child Hlth MARCH Ctr, London, England
关键词
NEURODEVELOPMENTAL IMPAIRMENT; PREGNANT-WOMEN; WORLDWIDE; ILAE; STILLBIRTHS; SEIZURES; OUTCOMES; CHILDREN; INFANCY; BURDEN;
D O I
10.1001/jamanetworkopen.2023.9507
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
IMPORTANCE The risk of epilepsy after neonatal invasive Group B Streptococcus (iGBS) disease, particularly iGBS sepsis, is poorly understood. OBJECTIVE To examine the association between neonatal iGBS (sepsis or meningitis) and long-term risk of epilepsy, stratified by sex, prematurity, and maternal socioeconomic position (SEP). DESIGN, SETTING, AND PARTICIPANTS This population-based cohort study was conducted in Denmark with an inclusion period from 1997 through 2017 and follow-up until the end of 2018. A general population comparison cohort was randomly sampled and matched up to 10:1 to the exposed cohort. Linkage between Danish national registers were applied for data collection. Participants were infants aged 0 to 89 days. The general population comparison cohort was matched by sex, the child's year and month of birth, and gestational age. SEP was defined by maternal income and education. EXPOSURE Hospital-diagnosed iGBS (sepsis or meningitis) during the first 89 days after birth. OUTCOMES AND MEASURES Epilepsy was defined by International Statistical Classification of Diseases and Related Health Problems, Tenth Revision codes and/or prescription codes for antiepileptic drugs using Danish medical registry data. Cumulative risk (CR) of epilepsy was calculated by treating death as a competing event. Cox proportional hazards regression was used to estimate hazard ratios with 95% CIs. Effect modification by sex, prematurity, and maternal SEP was assessed on an additive scale. RESULTS A total of 1432 children (792 [55.3%] boys; 1126 [78.6%] with gestational age >= 37 weeks) were identified with iGBS disease: 1264 with sepsis and 168 with meningitis. In the comparison cohort, there were 14211 children (7869 [55.4%] boys; 11260 [79.2%] with gestational age >= 37 weeks). The overall (0 to 22 years) CR of epilepsy was 3.6% (95% CI, 2.6%-5.0%) in children with iGBS disease and 2.3% (95% CI, 1.9%-2.7%) in the comparison cohort. The overall CR of epilepsy for iGBS meningitis was 15.1% (95% CI, 8.9%-22.8%) and 2.2% (95% CI, 1.4%-3.4%) for iGBS sepsis. The adjusted hazard ratio for epilepsy in children with iGBS disease was 2.04 (95% CI, 1.46-2.85). Being a boy, born premature, or born to a mother belonging to a low SEP group was associated with an increased risk of epilepsy in later childhood. CONCLUSION In this population-based cohort study of 1432 neonates, iGBS disease was associated with a higher incidence of epilepsy in later childhood, notably after meningitis. Premature birth, sex, and low maternal SEP modified the association.
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页数:12
相关论文
共 37 条
  • [21] Epilepsy and Neurodevelopmental Outcomes in Children With Etiologically Diagnosed Central Nervous System Infections: A Retrospective Cohort Study
    Lin, Chien-Heng
    Lin, Wei-De
    Chou, I-Ching
    Lee, Inn-Chi
    Hong, Syuan-Yu
    [J]. FRONTIERS IN NEUROLOGY, 2019, 10
  • [22] Infant Group B Streptococcal Disease Incidence and Serotypes Worldwide: Systematic Review and Meta-analyses
    Madrid, Lola
    Seale, Anna C.
    Kohli-Lynch, Maya
    Edmond, Karen M.
    Lawn, Joy E.
    Heath, Paul T.
    Madhi, Shabir A.
    Baker, Carol J.
    Bartlett, Linda
    Cutland, Clare
    Gravett, Michael G.
    Ip, Margaret
    Le Doare, Kirsty
    Rubens, Craig E.
    Saha, Samir K.
    Sobanjo-ter Meulen, Ajoke
    Vekemans, Johan
    Schrag, Stephanie
    [J]. CLINICAL INFECTIOUS DISEASES, 2017, 65 : S160 - S172
  • [23] The Danish Psychiatric Central Research Register
    Mors, Ole
    Perto, Gurli P.
    Mortensen, Preben Bo
    [J]. SCANDINAVIAN JOURNAL OF PUBLIC HEALTH, 2011, 39 : 54 - 57
  • [24] MunkJorgensen P, 1997, DAN MED BULL, V44, P82
  • [25] Neurodevelopmental Impairment at 1 Year of Age in Infants With Previous Invasive Group B Streptococcal Sepsis and Meningitis
    Nakwa, Firdose L.
    Lala, Sanjay G.
    Madhi, Shabir A.
    Dangor, Ziyaad
    [J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2020, 39 (09) : 794 - 798
  • [26] Global Burden of Pediatric Neurological Disorders
    Newton, Charles Richard
    [J]. SEMINARS IN PEDIATRIC NEUROLOGY, 2018, 27 : 10 - 15
  • [27] Neurodevelopmental and growth outcomes after invasive Group B Streptococcus in early infancy : A multi-country matched cohort study in South Africa Mozambique, India, Kenya, and Argentina
    Paul, Proma
    Chandna, Jaya
    Procter, Simon R.
    Dangor, Ziyaad
    Leahy, Shannon
    Santhanam, Sridhar
    John, Hima B.
    Bassat, Quique
    Bramugy, Justina
    Bardaji, Azucena
    Abubakar, Amina
    Nasambu, Carophine
    Libster, Romina
    Yanotti, Clara Sanchez
    Seedat, Farah
    Horvath-Puho, Erzsebet
    Hossain, A. K. M. Tanvir
    Rahman, Qazi Sadeq-ur
    Jit, Mark
    Newton, Charles R.
    Milner, Kate
    Goncalves, Bronner P.
    Lawn, Joy E.
    [J]. ECLINICALMEDICINE, 2022, 47
  • [28] Data Resource Profile: The Danish National Prescription Registry
    Pottegard, Anton
    Schmidt, Sigrun Alba Johannesdottir
    Wallach-Kildemoes, Helle
    Sorensen, Henrik Toft
    Hallas, Jesper
    Schmidt, Morten
    [J]. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2017, 46 (03) : 798 - +
  • [29] The Danish health care system and epidemiological research: from health care contacts to database records
    Schmidt, Morten
    Schmidt, Sigrun Alba Johannesdottir
    Adelborg, Kasper
    Sundboll, Jens
    Laugesen, Kristina
    Ehrenstein, Vera
    Sorensen, Henrik Toft
    [J]. CLINICAL EPIDEMIOLOGY, 2019, 11 : 563 - 591
  • [30] The Danish National Patient Registry: a review of content, data quality, and research potential
    Schmidt, Morten
    Schmidt, Sigrun Alba Johannesdottir
    Sandegaard, Jakob Lynge
    Ehrenstein, Vera
    Pedersen, Lars
    Sorensen, Henrik Toft
    [J]. CLINICAL EPIDEMIOLOGY, 2015, 7 : 449 - 489