Progress on diagnostic and prognostic markers of pancreatic cancer

被引：12

作者：

Yang, Hong ^{[1
,2
]}

LI, Wan ^{[1
,2
]}

Ren, Liwen ^{[1
,2
]}

Yang, Yihu ^{[1
,2
]}

Zhang, Yizhi ^{[1
,2
]}

Ge, Binbin ^{[1
,2
]}

LI, Sha

Zheng, Xiangjin ^{[1
,2
]}

Liu, Jinyi ^{[1
,2
]}

Zhang, Sen ^{[1
,2
]}

DU, Guanhua ^{[1
,2
]}

Tang, Bo ^{[3
]}

Wang, Hongquan ^{[3
]}

Wang, Jinhua ^{[1
,2
]}

机构：

[1] State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Key Lab Drug Target Res & Drug Screen, Beijing 100050, Peoples R China

[3] Tianjin Med Univ, Canc Inst & Hosp, Natl Clin Res Ctr Canc, Tianjins Clin Res Ctr Canc,Key Lab Canc Prevent &, Tianjin 300060, Peoples R China

来源：

ONCOLOGY RESEARCH | 2023年 / 31卷 / 02期

基金：

北京市自然科学基金; 中国国家自然科学基金;

关键词：

Pancreatic cancer; Biomarkers; Liquid biopsy; Systematic review; ENDOTHELIAL GROWTH-FACTOR; CELL-ADHESION MOLECULES; DUCTAL ADENOCARCINOMA; CARCINOEMBRYONIC ANTIGEN; SERUM BIOMARKER; COPY NUMBER; STEM-CELLS; HISTONE H3; EXPRESSION; SURVIVAL;

D O I：

10.32604/or.2023.028905

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic cancer is a malignant disease characterized by low survival and high recurrence rate, whose patients are mostly at the stage of locally advanced or metastatic disease when first diagnosed. Early diagnosis is particularly important because prognostic/predictive markers help guide optimal individualized treatment regimens. So far, CA199 is the only biomarker for pancreatic cancer approved by the FDA, but its effectiveness is limited by low sensitivity and specificity. With recent advances in genomics, proteomics, metabolomics, and other analytical and sequencing technologies, the rapid acquisition and screening of biomarkers is now possible. Liquid biopsy also occupies a significant place due to its unique advantages. In this review, we systematically describe and evaluate the available biomarkers that have the greatest potential as vital tools in diagnosing and treating pancreatic cancer.

引用

页码：83 / 99

页数：17

共 117 条

[1]

[Anonymous], 2009, J CLIN ONCOL, DOI DOI 10.1200/JCO.2009.27

[2] Proteomic and genomic profiling of pancreatic cancer [J].

Ansari, Daniel ;

Toren, William ;

Zhou, Qimin ;

Hu, Dingyuan ;

Andersson, Roland .

CELL BIOLOGY AND TOXICOLOGY, 2019, 35 (04) :333-343

[3] Genomics-Driven Precision Medicine for Advanced Pancreatic Cancer: Early Results from the COMPASS Trial [J].

Aung, Kyaw L. ;

Fischer, Sandra E. ;

Denroche, Robert E. ;

Jang, Gun-Ho ;

Dodd, Anna ;

Creighton, Sean ;

Southwood, Bernadette ;

Liang, Sheng-Ben ;

Chadwick, Dianne ;

Zhang, Amy ;

O'Kane, Grainne M. ;

Albaba, Hamzeh ;

Moura, Shari ;

Grant, Robert C. ;

Miller, Jessica K. ;

Mbabaali, Faridah ;

Pasternack, Danielle ;

Lungu, Ilinca M. ;

Bartlett, John M. S. ;

Ghai, Sangeet ;

Lemire, Mathieu ;

Holter, Spring ;

Connor, Ashton A. ;

Moffitt, Richard A. ;

Yeh, Jen Jen ;

Timms, Lee ;

Krzyzanowski, Paul M. ;

Dhani, Neesha ;

Hedley, David ;

Notta, Faiyaz ;

Wilson, Julie M. ;

Moore, Malcolm J. ;

Gallinger, Steven ;

Knox, Jennifer J. .

CLINICAL CANCER RESEARCH, 2018, 24 (06) :1344-1354

[4] Biomarkers for pancreatic cancer: promising new markers and options beyond CA 19-9 [J].

Ballehaninna, Umashankar K. ;

Chamberlain, Ronald S. .

TUMOR BIOLOGY, 2013, 34 (06) :3279-3292

[5] Evaluation of tumor M2-pyruvate kinase (Tumor M2-PK) as a biomarker for pancreatic cancer [J].

Bandara, Indika A. ;

Baltatzis, Minas ;

Sanyal, Sudip ;

Siriwardena, Ajith K. .

WORLD JOURNAL OF SURGICAL ONCOLOGY, 2018, 16

[6] Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis [J].

Beauchemin, Nicole ;

Arabzadeh, Azadeh .

CANCER AND METASTASIS REVIEWS, 2013, 32 (3-4) :643-671

[7] Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies [J].

Bettegowda, Chetan ;

Sausen, Mark ;

Leary, Rebecca J. ;

Kinde, Isaac ;

Wang, Yuxuan ;

Agrawal, Nishant ;

Bartlett, Bjarne R. ;

Wang, Hao ;

Luber, Brandon ;

Alani, Rhoda M. ;

Antonarakis, Emmanuel S. ;

Azad, Nilofer S. ;

Bardelli, Alberto ;

Brem, Henry ;

Cameron, John L. ;

Lee, Clarence C. ;

Fecher, Leslie A. ;

Gallia, Gary L. ;

Gibbs, Peter ;

Le, Dung ;

Giuntoli, Robert L. ;

Goggins, Michael ;

Hogarty, Michael D. ;

Holdhoff, Matthias ;

Hong, Seung-Mo ;

Jiao, Yuchen ;

Juhl, Hartmut H. ;

Kim, Jenny J. ;

Siravegna, Giulia ;

Laheru, Daniel A. ;

Lauricella, Calogero ;

Lim, Michael ;

Lipson, Evan J. ;

Marie, Suely Kazue Nagahashi ;

Netto, George J. ;

Oliner, Kelly S. ;

Olivi, Alessandro ;

Olsson, Louise ;

Riggins, Gregory J. ;

Sartore-Bianchi, Andrea ;

Schmidt, Kerstin ;

Shih, Ie-Ming ;

Oba-Shinjo, Sueli Mieko ;

Siena, Salvatore ;

Theodorescu, Dan ;

Tie, Jeanne ;

Harkins, Timothy T. ;

Veronese, Silvio ;

Wang, Tian-Li ;

Weingart, Jon D. .

SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (224)

[8] BRCA1/BRCA2 Germline Mutation Carriers and Sporadic Pancreatic Ductal Adenocarcinoma [J].

Blair, Alex B. ;

Groot, Vincent P. ;

Gemenetzis, Georgios ;

Wei, Jishu ;

Cameron, John L. ;

Weiss, Matthew J. ;

Goggins, Michael ;

Wolfgang, Christopher L. ;

Yu, Jun ;

He, Jin .

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2018, 226 (04) :630-637

[9]

Botezatu A, 2015, CANCER GENOM PROTEOM, V12, P21

[10] KRAS G12D Mutation Subtype Is A Prognostic Factor for Advanced Pancreatic Adenocarcinoma [J].

Bournet, Barbara ;

Muscari, Fabrice ;

Buscail, Camille ;

Assenat, Eric ;

Barthet, Marc ;

Hammel, Pascal ;

Selves, Janick ;

Guimbaud, Rosine ;

Cordelier, Pierre ;

Buscail, Louis .

CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY, 2016, 7 :E157

← 1 2 3 4 5 6 7 8 9 10 →