First-in-human liver transplantation from a centenarian deceased donor after brain death

被引：4

作者：

De Simone, Paolo ^{[1
,2
]}

Ghinolfi, Davide ^{[1
]}

Palladino, Simona ^{[1
]}

Catalano, Gabriele ^{[1
]}

Martinelli, Caterina ^{[1
]}

Ducci, Juri ^{[1
]}

Bronzoni, Jessica ^{[1
]}

Tincani, Giovanni ^{[1
]}

Balzano, Emanuele ^{[1
]}

Carrai, Paola ^{[1
]}

Petruccelli, Stefania ^{[1
]}

Campani, Daniela ^{[2
,3
]}

Crocetti, Laura ^{[2
,4
]}

Lazzeri, Chiara ^{[6
]}

Biancofiore, Giandomenico ^{[2
,5
]}

Peris, Adriano ^{[7
]}

机构：

[1] Univ Pisa, Hepatobiliary Surg & Liver Transplantat, Med Sch Hosp, Via Paradisa 2, I-56124 Pisa, Italy

[2] Univ Pisa, Dept Surg Med Biochem Pathol & Intens Care, Pisa, Italy

[3] Univ Pisa, Dept Pathol, Med Sch Hosp, Pisa, Italy

[4] Univ Pisa, Intervent Radiol, Med Sch Hosp, Pisa, Italy

[5] Univ Pisa, Anesthesiol & Intens Care, Med Sch Hosp, Pisa, Italy

[6] Careggi Hosp, Reg Ctr Organ & Tissue Allocat, Florence, Italy

[7] Tuscany Reg Welf Minist, Org Toscana Trapianti, Florence, Italy

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2024年 / 24卷 / 02期

关键词：

elderly donors; hepatocellular carcinoma; Immunotherapy; machine perfusion;

D O I：

10.1016/j.ajt.2023.09.014

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Liver transplantation from elderly donors is expanding due to demand for liver grafts, aging of recipients and donors, and introduction of machine perfusion. We report on a liver transplant from a 100-year-old deceased donor after brain death. The liver was transplanted after the use of hypothermic machine perfusion to a 60-year-old recipient with advanced hepatocellular carcinoma undergoing neoadjuvant immunotherapy. Nine months after the transplant, the patient is alive with a functioning graft and no evidence of acute rejection or tumor recurrence.

引用

页码：304 / 307

页数：4

共 50 条

[1] Should We Perform Deceased Donor Liver Transplantation After Living Donor Liver Transplantation Has Failed?
Greig, Paul D.
Geier, Andreas
D'Alessandro, Anthony M.
Campbell, Michael
Wright, Linda
LIVER TRANSPLANTATION, 2011, 17 : S139 - S146
[2] Is living donor liver transplantation really equivalent to deceased donor liver transplantation?
Ohdan, Hideki
TRANSPLANT INTERNATIONAL, 2013, 26 (08) : 778 - 779
[3] Outcomes of Living Donor Liver Transplantation Compared with Deceased Donor Liver Transplantation
Tulla, Kiara A.
Tinney Jr, Francis J.
Cameron, Andrew M.
SURGICAL CLINICS OF NORTH AMERICA, 2024, 104 (01) : 79 - 88
[4] Impact of donor sex on hepatocellular carcinoma recurrence in liver transplantation after brain death
Nakamura, Tsukasa
Sasaki, Kazunari
Kojima, Lisa
Teo, Richard
Inaba, Yosuke
Yamamoto, Takayuki
Kimura, Shoko
Dageforde, Leigh Anne
Yeh, Heidi
Elias, Nahel
Bozorgzadeh, Adel
Kawai, Tatsuo
Markmann, James F.
CLINICAL TRANSPLANTATION, 2023, 37 (08)
[5] Living Donor Versus Deceased Donor Liver Transplantation for HCC
Sait Murat Doğan
Koray Kutlutürk
Journal of Gastrointestinal Cancer, 2020, 51 : 1104 - 1106
[6] Living Donor Versus Deceased Donor Liver Transplantation for HCC
Dogan, Sait Murat
Kutluturk, Koray
JOURNAL OF GASTROINTESTINAL CANCER, 2020, 51 (04) : 1104 - 1106
[7] The clinical outcomes of patients with vascular invasion after deceased donor liver transplantation
Ye, Zhaodan
Zhuang, Li
Liu, Xiangyan
Song, Mengchen
Zhang, Jingfeng
Gao, Guohong
JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2024, 15 (04) : 1686 - 1697
[8] Pushing the donor limits: Deceased donor liver transplantation using organs from octogenarian donors
Diaz Jaime, Francia
Berenguer, Marina
LIVER TRANSPLANTATION, 2017, 23 : S22 - S26
[9] Heparin Conjugate Pretreatment of Kidneys From Deceased Donors Before Transplantation: Results From the First-in-human Randomized Phase I Trial
Sedigh, Amir
Lundgren, Torbjorn
Lindner, Per
Nordstrom, Johan
Magnusson, Peetra
Jonsson, Janniz
Carlsson, Fredrik
Ploeg, Rutger
Lorant, Tomas
TRANSPLANTATION DIRECT, 2023, 9 (01): : E1403
[10] Outcome of hepatocellular carcinoma treated by liver transplantation:comparison of living donor and deceased donor transplantation
Chuan Li
Hepatobiliary & Pancreatic Diseases International, 2010, 9 (04) : 366 - 369

← 1 2 3 4 5 →