This case report presents a rare occurrence of basal cell carcinoma (BCC) in the periungual region of the thumb. BCC is the most common type of skin cancer, typically found in sun-exposed areas. The discussion explores the underlying pathogenesis mechanisms, including the role of ultraviolet exposure, the absence of pilosebaceous units, and the involvement of the sonic hedgehog (SHH) pathway. Understanding the complexities of BCC in atypical locations is essential for effective prevention and treatment strategies.
机构:Henry Ford Hlth Syst, Dept Dermatol, Div Mohs Microg Surg, Detroit, MI 48202 USA
Iwasaki, Julie K.
Srivastava, Divya
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Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USAHenry Ford Hlth Syst, Dept Dermatol, Div Mohs Microg Surg, Detroit, MI 48202 USA
Srivastava, Divya
Moy, Ronald L.
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Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA
W Los Angeles Vet Affairs Med Ctr, Los Angeles, CA USAHenry Ford Hlth Syst, Dept Dermatol, Div Mohs Microg Surg, Detroit, MI 48202 USA
Moy, Ronald L.
Lin, Henry J.
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Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA
Harbor UCLA Med Ctr, Dept Pediat, Torrance, CA 90509 USA
Harbor UCLA Med Ctr, Div Med Genet, Torrance, CA 90509 USAHenry Ford Hlth Syst, Dept Dermatol, Div Mohs Microg Surg, Detroit, MI 48202 USA
Lin, Henry J.
Kouba, David J.
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Henry Ford Hlth Syst, Dept Dermatol, Div Mohs Microg Surg, Detroit, MI 48202 USA
Toledo Clin Dermasurg & Laser Ctr, Toledo, OH USAHenry Ford Hlth Syst, Dept Dermatol, Div Mohs Microg Surg, Detroit, MI 48202 USA
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FMABC, Postgrad Res & Innovat Ctr, Santo Andre, SP, BrazilFMABC, Postgrad Res & Innovat Ctr, Santo Andre, SP, Brazil
Montagna, Erik
Lopes, Otavio Sergio
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Clin Dermatol Santa Catarina, Res Ctr, Joao Pessoa, PB, Brazil
Fac Med Sci Santa Casa Sao Paulo FCMSCSP, Dept Dermatol, Sao Paulo, SP, BrazilFMABC, Postgrad Res & Innovat Ctr, Santo Andre, SP, Brazil
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Univ Arkansas Med Sci, Dept Radiat Oncol, 4301 W Markham Rd, Little Rock, AR 72205 USAUniv Arkansas Med Sci, Dept Radiat Oncol, 4301 W Markham Rd, Little Rock, AR 72205 USA
Wang, Kaidi
Patel, Mausam
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Univ Arkansas Med Sci, Dept Radiat Oncol, 4301 W Markham Rd, Little Rock, AR 72205 USAUniv Arkansas Med Sci, Dept Radiat Oncol, 4301 W Markham Rd, Little Rock, AR 72205 USA
Patel, Mausam
Prabhu, Arpan, V
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Univ Arkansas Med Sci, Dept Radiat Oncol, 4301 W Markham Rd, Little Rock, AR 72205 USAUniv Arkansas Med Sci, Dept Radiat Oncol, 4301 W Markham Rd, Little Rock, AR 72205 USA
Prabhu, Arpan, V
Lewis, Gary D.
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Univ Arkansas Med Sci, Dept Radiat Oncol, 4301 W Markham Rd, Little Rock, AR 72205 USAUniv Arkansas Med Sci, Dept Radiat Oncol, 4301 W Markham Rd, Little Rock, AR 72205 USA
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Childrens Hosp Oakland, Res Inst, Canc Div, Oakland, CA 94609 USAChildrens Hosp Oakland, Res Inst, Canc Div, Oakland, CA 94609 USA
So, Po-Lin
Tang, Jean Y.
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Childrens Hosp Oakland, Res Inst, Canc Div, Oakland, CA 94609 USA
Stanford Sch Med, Redwood City, CA 94063 USAChildrens Hosp Oakland, Res Inst, Canc Div, Oakland, CA 94609 USA
Tang, Jean Y.
Epstein, Ervin H.
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Childrens Hosp Oakland, Res Inst, Canc Div, Oakland, CA 94609 USAChildrens Hosp Oakland, Res Inst, Canc Div, Oakland, CA 94609 USA