S1P/S1PR signaling pathway advancements in autoimmune diseases

被引：16
作者：
Li, Jianbin [1 ]
Huang, Yiping [1 ]
Zhang, Yueqin [1 ]
Liu, Pengcheng [1 ]
Liu, Mengxia [1 ]
Zhang, Min [1 ]
Wu, Rui [1 ]
机构：
[1] Nanchang Univ, Dept Rheumatol & Immunol, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R China
来源：
BIOMOLECULES AND BIOMEDICINE | 2023年 / 23卷 / 06期
基金：
英国科研创新办公室;
关键词：
Sphingosine-1-phosphate (S1P); sphingosine-1-phosphate receptor (S1PR); S1P; S1PR signaling pathway; autoimmune diseases; research progress; SPHINGOSINE; 1-PHOSPHATE; SYSTEMIC-SCLEROSIS; MULTIPLE-SCLEROSIS; SPHINGOSINE-1-PHOSPHATE RECEPTOR-3; OSTEOCLAST PRECURSORS; S1P; EXPRESSION; KINASE; CELLS; ACTIVATION;
D O I：
10.17305/bb.2023.9082
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Sphingosine-1-phosphate (S1P) is a versatile sphingolipid that is generated through the phosphorylation of sphingosine by sphingosine kinase (SPHK). S1P exerts its functional effects by binding to the G protein-coupled S1P receptor (S1PR). This lipid mediator plays a pivotal role in various cellular activities. The S1P/S1PR signaling pathway is implicated in the pathogenesis of immune-mediated diseases, significantly contributing to the functioning of the immune system. It plays a crucial role in diverse physiological and pathophysiological processes, including cell survival, proliferation, migration, immune cell recruitment, synthesis of inflammatory mediators, and the formation of lymphatic and blood vessels. However, the full extent of the involvement of this signaling pathway in the development of autoimmune diseases remains to be fully elucidated. Therefore, this study aims to comprehensively review recent research on the S1P/S1PR axis in diseases related to autoimmunity.
引用
收藏
页码：922 / 935
页数：14
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