Transforming growth factor-beta superfamily regulates mesenchymal stem cell osteogenic differentiation: A microRNA linking

被引：4
|
作者：
Santibanez, Juan F. [1 ,2 ,8 ]
Echeverria, Cesar [3 ]
Millan, Carola [4 ]
Simon, Felipe [5 ,6 ,7 ]
机构：
[1] Univ Belgrade, Inst Med Res, Natl Inst Republ Serbia, Grp Mol Oncol, Dr Subotica 4,POB 102, Belgrade 11129, Serbia
[2] Bernardo O Higgins Univ, Integrat Ctr Biol & Appl Chem CIBQA, Gen Gana 1780, Santiago 8370854, Chile
[3] Univ Atacama, Fac Med, Lab Mol Biol Nanomed & Genom, Copiapo 1532502, Chile
[4] Adolfo Ibanez Univ, Fac Liberal Arts, Dept Sci, Vina Del Mar, Chile
[5] Univ Andres Bello, Fac Life Sci, Lab Integrat Physiopathol, Santiago, Chile
[6] Millennium Inst Immunol & Immunotherapy, Santiago, Chile
[7] Univ Chile, Millennium Nucleus Ion Channel Associated Dis, Santiago, Chile
[8] Univ Belgrade, Inst Med Res, Natl Inst Republ Serbia, Grp Mol Oncol, Dr Subotica 4,POB 102, Belgrade 11129, Serbia
来源：
ACTA HISTOCHEMICA | 2023年 / 125卷 / 08期
关键词：
Mesenchymal Stem Cells; Bone Morphogenetic Proteins; Osteogenic; Differentiation; MicroRNA; Transforming GrowthFactor-beta; TGF-BETA; OSTEOBLAST DIFFERENTIATION; BONE-FORMATION; STROMAL CELLS; TRANSCRIPTIONAL CONTROL; SIGNALING PATHWAY; TARGETING SMAD7; MESSENGER-RNA; EXPRESSION; PROLIFERATION;
D O I：
10.1016/j.acthis.2023.152096
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The ability to differentiate into cells of different lineages, such as bone cells, is the principal value of adult mesenchymal stem cells (MSCs), which can be used with the final aim of regenerating damaged tissue. Due to its potential use and importance in regenerative medicine and tissue engineering, several questions have been raised regarding the molecular mechanisms of MSC differentiation. As one of the crucial mediators in organism development, the transforming growth factor-beta (TGF-beta) superfamily directs MSCs' commitment to selecting differentiation pathways. This review aims to give an overview of the current knowledge on the mechanisms of the TGF-beta superfamily in MSCs bone differentiation, with additional insight into the mutual regulation of microRNAs and TGF-beta in osteogenesis.
引用
收藏
页数：11
相关论文
共 50 条
  • [31] Nucleotides metabolizing ectoenzymes as possible markers of mesenchymal stem cell osteogenic differentiation
    Roszek, Katarzyna
    Blaszczak, Agnieszka
    Wujak, Magdalena
    Komoszynski, Michal
    BIOCHEMISTRY AND CELL BIOLOGY, 2013, 91 (03) : 176 - 181
  • [32] Transforming Growth Factor-Beta in Skeletal Muscle Wasting
    Klein, Gordon L.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (03)
  • [33] Correlation between Oxidative Stress and Transforming Growth Factor-Beta in Cancers
    Chung, Jinwook
    Huda, Md Nazmul
    Shin, Yoonhwa
    Han, Sunhee
    Akter, Salima
    Kang, Insug
    Ha, Joohun
    Choe, Wonchae
    Choi, Tae Gyu
    Kim, Sung Soo
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (24)
  • [34] Transforming Growth Factor-Beta and Urokinase Type Plasminoge Interplay in Cancer
    Santibanez, Juan F.
    Krstic, Jelena
    CURRENT PROTEIN & PEPTIDE SCIENCE, 2018, 19 (12) : 1155 - 1163
  • [35] Review: Targeting the Transforming Growth Factor-Beta Pathway in Ovarian Cancer
    Roane, Brandon M.
    Arend, Rebecca C.
    Birrer, Michael J.
    CANCERS, 2019, 11 (05)
  • [36] The evidence for the role of transforming growth factor-beta in the formation of abnormal scarring
    Chalmers, Richard L.
    INTERNATIONAL WOUND JOURNAL, 2011, 8 (03) : 218 - 223
  • [37] microRNA-34a inhibits epithelial mesenchymal transition in human cholangiocarcinoma by targeting Smad4 through transforming growth factor-beta/Smad pathway
    Qiao, Pengfei
    Li, Guodong
    Bi, Wen
    Yang, Lianmeng
    Yao, Lei
    Wu, Dequan
    BMC CANCER, 2015, 15
  • [38] MicroRNA Regulation in Osteogenic and Adipogenic Differentiation of Bone Mesenchymal Stem Cells and its Application in Bone Regeneration
    Li, Binbin
    CURRENT STEM CELL RESEARCH & THERAPY, 2018, 13 (01) : 26 - 30
  • [39] Combinations of growth factors for human mesenchymal stem cell proliferation and osteogenic differentiation
    Blahnova, V. Hefka
    Dankova, J.
    Rampichova, M.
    Filova, E.
    BONE & JOINT RESEARCH, 2020, 9 (07): : 412 - 420
  • [40] Recent development in pleiotropic effects of statins on cardiovascular disease through regulation of transforming growth factor-beta superfamily
    Ma, Sze
    Ma, Christopher Cheng-Hwa
    CYTOKINE & GROWTH FACTOR REVIEWS, 2011, 22 (03) : 167 - 175
12345