Transforming growth factor-beta superfamily regulates mesenchymal stem cell osteogenic differentiation: A microRNA linking

被引：4

作者：

Santibanez, Juan F. ^{[1
,2
,8
]}

Echeverria, Cesar ^{[3
]}

Millan, Carola ^{[4
]}

Simon, Felipe ^{[5
,6
,7
]}

机构：

[1] Univ Belgrade, Inst Med Res, Natl Inst Republ Serbia, Grp Mol Oncol, Dr Subotica 4,POB 102, Belgrade 11129, Serbia

[2] Bernardo O Higgins Univ, Integrat Ctr Biol & Appl Chem CIBQA, Gen Gana 1780, Santiago 8370854, Chile

[3] Univ Atacama, Fac Med, Lab Mol Biol Nanomed & Genom, Copiapo 1532502, Chile

[4] Adolfo Ibanez Univ, Fac Liberal Arts, Dept Sci, Vina Del Mar, Chile

[5] Univ Andres Bello, Fac Life Sci, Lab Integrat Physiopathol, Santiago, Chile

[6] Millennium Inst Immunol & Immunotherapy, Santiago, Chile

[7] Univ Chile, Millennium Nucleus Ion Channel Associated Dis, Santiago, Chile

[8] Univ Belgrade, Inst Med Res, Natl Inst Republ Serbia, Grp Mol Oncol, Dr Subotica 4,POB 102, Belgrade 11129, Serbia

来源：

ACTA HISTOCHEMICA | 2023年 / 125卷 / 08期

关键词：

Mesenchymal Stem Cells; Bone Morphogenetic Proteins; Osteogenic; Differentiation; MicroRNA; Transforming GrowthFactor-beta; TGF-BETA; OSTEOBLAST DIFFERENTIATION; BONE-FORMATION; STROMAL CELLS; TRANSCRIPTIONAL CONTROL; SIGNALING PATHWAY; TARGETING SMAD7; MESSENGER-RNA; EXPRESSION; PROLIFERATION;

D O I：

10.1016/j.acthis.2023.152096

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The ability to differentiate into cells of different lineages, such as bone cells, is the principal value of adult mesenchymal stem cells (MSCs), which can be used with the final aim of regenerating damaged tissue. Due to its potential use and importance in regenerative medicine and tissue engineering, several questions have been raised regarding the molecular mechanisms of MSC differentiation. As one of the crucial mediators in organism development, the transforming growth factor-beta (TGF-beta) superfamily directs MSCs' commitment to selecting differentiation pathways. This review aims to give an overview of the current knowledge on the mechanisms of the TGF-beta superfamily in MSCs bone differentiation, with additional insight into the mutual regulation of microRNAs and TGF-beta in osteogenesis.

引用

页数：11

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