Non-Genomic Hallmarks of Aging-The Review

被引：6

作者：

Holmannova, Drahomira ^{[1
]}

Borsky, Pavel ^{[1
]}

Parova, Helena ^{[2
]}

Stverakova, Tereza ^{[2
]}

Vosmik, Milan ^{[3
]}

Hruska, Libor ^{[3
]}

Fiala, Zdenek ^{[1
]}

Borska, Lenka ^{[1
]}

机构：

[1] Charles Univ Prague, Inst Prevent Med, Fac Med Hradec Kralove, Hradec Kralove 50003, Czech Republic

[2] Charles Univ Prague, Univ Hosp, Fac Med Hradec Kralove, Dept Clin Biochem & Diagnost, Hradec Kralove 50003, Czech Republic

[3] Charles Univ Prague, Univ Hosp, Fac Med Hradec Kralove, Dept Oncol & Radiotherapy, Hradec Kralove 50003, Czech Republic

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 20期

关键词：

aging; hallmarks; non-genomic; cancer; GLYCATION END-PRODUCTS; AGE-RELATED-CHANGES; IGF-I; CELLULAR SENESCENCE; RESPIRATORY-CHAIN; PREDICTS SURVIVAL; OXIDATIVE STRESS; CANCER; CELLS; EXPRESSION;

D O I：

10.3390/ijms242015468

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aging is a natural, gradual, and inevitable process associated with a series of changes at the molecular, cellular, and tissue levels that can lead to an increased risk of many diseases, including cancer. The most significant changes at the genomic level (DNA damage, telomere shortening, epigenetic changes) and non-genomic changes are referred to as hallmarks of aging. The hallmarks of aging and cancer are intertwined. Many studies have focused on genomic hallmarks, but non-genomic hallmarks are also important and may additionally cause genomic damage and increase the expression of genomic hallmarks. Understanding the non-genomic hallmarks of aging and cancer, and how they are intertwined, may lead to the development of approaches that could influence these hallmarks and thus function not only to slow aging but also to prevent cancer. In this review, we focus on non-genomic changes. We discuss cell senescence, disruption of proteostasis, deregualation of nutrient sensing, dysregulation of immune system function, intercellular communication, mitochondrial dysfunction, stem cell exhaustion and dysbiosis.

引用

页数：29

共 221 条

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