Bidirectionality between Cardiometabolic Diseases and COVID-19: Role of Humoral Immunity

被引:0
作者
Yu, Elaine A. [1 ,2 ]
Jackman, Rachael P. [1 ,2 ]
Glesby, Marshall J. [3 ]
Narayan, K. M. Venkat [4 ,5 ]
机构
[1] Vitalant Res Inst, San Francisco, CA 94105 USA
[2] Univ Calif San Francisco, San Francisco, CA 94118 USA
[3] Weill Cornell Med, Div Infect Dis, New York, NY USA
[4] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA USA
[5] Emory Univ, Emory Global Diabet Res Ctr, Woodruff Hlth Sci Ctr, Atlanta, GA USA
关键词
SARS-CoV-2; antibodies; diabetes; obesity; cardiovascular diseases; HEALTH-CARE WORKERS; NEW-YORK-CITY; SARS-COV-2; ANTIBODIES; INFECTION; VACCINE; ASSOCIATIONS; ENGLAND; OBESITY; IGG; INDIVIDUALS;
D O I
10.1016/j.advnut.2023.06.003
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Cardiometabolic diseases and abnormalities have recently emerged as independent risk factors of coronavirus disease 2019 (COVID-19) severity, including hospitalizations, invasive mechanical ventilation, and mortality. Determining whether and how this observation translates to more effective long-term pandemic mitigation strategies remains a challenge due to key research gaps. Specific pathways by which cardiometabolic pathophysiology affects humoral immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and vice versa, remain unclear. This review summarizes current evidence of the bidirectional influences between cardiometabolic diseases (diabetes, adiposity, hypertension, CVDs) and SARS-CoV-2 antibodies induced from infection and vaccination based on human studies. Ninety-two studies among >408,000 participants in 37 countries on 5 continents (Europe, Asia, Africa, and North and South America) were included in this review. Obesity was associated with higher neutralizing antibody titers following SARS-CoV-2 infection. Most studies conducted prior to vaccinations found positive or null associations between binding antibodies (levels, seropositivity) and diabetes; after vaccinations, antibody responses did not differ by diabetes. Hypertension and CVDs were not associated with SARS-CoV-2 antibodies. Findings underscore the importance of elucidating the extent that tailored recommendations for COVID-19 prevention, vaccination effec-tiveness, screening, and diagnoses among people with obesity could reduce disease burden caused by SARS-CoV-2.
引用
收藏
页码:1145 / 1158
页数:14
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