Exosomal microRNAs and long noncoding RNAs: as novel biomarkers for endometriosis

被引:6
作者
Soltani-Fard, Elahe [1 ]
Asadi, Marzieh [2 ,4 ]
Taghvimi, Sina [3 ]
Vafadar, Asma [2 ,4 ]
Vosough, Parisa [2 ,4 ]
Tajbakhsh, Amir [5 ,6 ]
Savardashtaki, Amir [2 ,7 ]
机构
[1] Shahrekord Univ Med Sci, Sch Adv Technol, Dept Mol Med, Shahrekord, Iran
[2] Shiraz Univ Med Sci, Sch Adv Med Sci & Technol, Dept Med Biotechnol, Shiraz 7136281407, Iran
[3] Shahid Chamran Univ Ahvaz, Fac Sci, Dept Biol, Ahvaz, Iran
[4] Shiraz Univ Med Sci, Student Res Comm, Shiraz, Iran
[5] Shiraz Univ Med Sci, Pharmaceut Sci Res Ctr, Shiraz, Iran
[6] Shiraz Univ Med Sci, Sch Adv Med Sci & Technol, Dept Mol Med, Shiraz, Iran
[7] Shiraz Univ Med Sci, Infertil Res Ctr, Shiraz, Iran
关键词
Endometriosis; Exosome; Exosomal long noncoding RNAs; Exosomal microRNAs; Noncoding RNAs; STROMAL CELLS; EXTRACELLULAR VESICLES; EUTOPIC ENDOMETRIUM; CONTRACEPTIVE RING; HOTAIR PROMOTES; CANCER CELLS; ANGIOGENESIS; PROLIFERATION; WOMEN; SUPPRESSES;
D O I
10.1007/s00441-023-03802-5
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Endometriosis is a gynecological inflammatory disorder characterized by the development of endometrial-like cells outside the uterine cavity. This disease is associated with a wide range of clinical presentations, such as debilitating pelvic pain and infertility issues. Endometriosis diagnosis is not easily discovered by ultrasound or clinical examination. Indeed, difficulties in noninvasive endometriosis diagnosis delay the confirmation and management of the disorder, increase symptoms, and place a significant medical and financial burden on patients. So, identifying specific and sensitive biomarkers for this disease should therefore be a top goal. Exosomes are extracellular vesicles secreted by most cell types. They transport between cells' bioactive molecules such as noncoding RNAs and proteins. MicroRNAs and long noncoding RNAs which are key molecules transferred by exosomes have recently been identified to have a significant role in endometriosis by modulating different proteins and their related genes. As a result, the current review focuses on exosomal micro-and-long noncoding RNAs that are involved in endometriosis disease. Furthermore, major molecular mechanisms linking corresponding RNA molecules to endometriosis development will be briefly discussed to better clarify the potential functions of exosomal noncoding RNAs in the therapy and diagnosis of endometriosis.
引用
收藏
页码:55 / 74
页数:20
相关论文
共 170 条
[1]  
Agarwal Neha, 2010, J Lab Physicians, V2, P1, DOI 10.4103/0974-2727.66699
[2]   Molecular Evidence for Differences in Endometrium in Severe Versus Mild Endometriosis [J].
Aghajanova, Lusine ;
Giudice, Linda C. .
REPRODUCTIVE SCIENCES, 2011, 18 (03) :229-251
[3]   Biomarkers in endometriosis: challenges and opportunities [J].
Ahn, Soo Hyun ;
Singh, Vinay ;
Tayade, Chandrakant .
FERTILITY AND STERILITY, 2017, 107 (03) :523-532
[4]   microRNAs Biogenesis, Functions and Role in Tumor Angiogenesis [J].
Annese, Tiziana ;
Tamma, Roberto ;
De Giorgis, Michelina ;
Ribatti, Domenico .
FRONTIERS IN ONCOLOGY, 2020, 10
[5]  
Ardekani Ali M., 2010, Avicenna Journal of Medical Biotechnology, V2, P161
[6]   Caspase-3: Structure, function, and biotechnological aspects [J].
Asadi, Marzieh ;
Taghizadeh, Saeed ;
Kaviani, Elina ;
Vakili, Omid ;
Taheri-Anganeh, Mortaza ;
Tahamtan, Mahshid ;
Savardashtaki, Amir .
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 2022, 69 (04) :1633-1645
[7]   Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review [J].
Azmi, Asfar S. ;
Bao, Bin ;
Sarkar, Fazlul H. .
CANCER AND METASTASIS REVIEWS, 2013, 32 (3-4) :623-642
[8]   PTEN and miR-26b: Promising prognostic biomarkers in initiation and progression of Oral Squamous Cell Carcinoma [J].
Baghaei, Fereshteh ;
Abdollahi, Alireza ;
Mohammadpour, Hadiseh ;
Jahanbin, Mahsa ;
Taheri, Fatemeh Naseri ;
Aminishakib, Pouyan ;
Razavi, Amirnader Emami ;
Kharazifard, Mohamadjavad .
JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2019, 48 (01) :31-35
[9]   Critical Review of the Evolution of Extracellular Vesicles' Knowledge: From 1946 to Today [J].
Bazzan, Erica ;
Tine, Mariaenrica ;
Casara, Alvise ;
Biondini, Davide ;
Semenzato, Umberto ;
Cocconcelli, Elisabetta ;
Balestro, Elisabetta ;
Damin, Marco ;
Radu, Claudia Maria ;
Turato, Graziella ;
Baraldo, Simonetta ;
Simioni, Paolo ;
Spagnolo, Paolo ;
Saetta, Marina ;
Cosio, Manuel G. .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (12)
[10]   The regulation of CD47-SIRPα signaling axis by microRNAs in combination with conventional cytotoxic drugs together with the help of nano-delivery: a choice for therapy? [J].
Beizavi, Zahra ;
Gheibihayat, Seyed Mohammad ;
Moghadasian, Hadis ;
Zare, Hossein ;
Yeganeh, Babak Shirazi ;
Askari, Hassan ;
Vakili, Sina ;
Tajbakhsh, Amir ;
Savardashtaki, Amir .
MOLECULAR BIOLOGY REPORTS, 2021, 48 (07) :5707-5722