Jointly Depleting Glutathione Based on Self-Assembled Nanomicelles for Enhancing Photodynamic Therapy

被引：0

作者：

Wu, Jingxi ^{[1
]}

Shang, Jingjing ^{[1
]}

An, Jing ^{[1
]}

Chen, Wenlong ^{[1
]}

Hong, Gaobo ^{[1
]}

Hou, Haoran ^{[1
]}

Zheng, Wen-Heng ^{[2
]}

Song, Fengling ^{[1
,3
]}

Peng, Xiaojun ^{[1
]}

机构：

[1] Dalian Univ Technol, Frontiers Sci Ctr Smart Mat Oriented Chem Engn, State Key Lab Fine Chem, Dalian 116024, Peoples R China

[2] Dalian Univ Technol, Liaoning Canc Hosp & Inst, Dept Intervent Therapy, Canc Hosp, Shenyang 110042, Peoples R China

[3] Shandong Univ, Inst Mol Sci & Engn, Inst Frontier & Interdisciplinary Sci, Qingdao 266237, Peoples R China

来源：

CHEMBIOCHEM | 2023年 / 24卷 / 16期

基金：

中国国家自然科学基金;

关键词：

Activatable photosensitizer; Glutathione; Nanomicelles; Photodynamic therapy; Self-assembly; IN-VITRO; NANOPARTICLES; CURCUMIN; FLUORESCENCE; INHIBITION; NANOSYSTEM; RELEASE; CELLS;

D O I：

10.1002/cbic.202300323

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Photodynamic therapy (PDT) is one common ROS-generating therapeutic method with high tumor selectivity and low side effects. But the GSH-upregulation often alleviates its therapeutic efficiency. Here, we proposed a new strategy of jointly depleting GSH to enhance the therapeutic effect of PDT by preparing a nanomicelle by self-assembly method from GSH-activated photosensitizer DMT, curcumin, and amphiphilic polymer TPGS.

引用

页数：5

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