High-fructose corn syrup intake increases hepatic mitochondrial DNA copy number and methylation in adolescent rats

被引：5

作者：

Mizuno, Genki ^{[1
,2
]}

Yamada, Hiroya ^{[3
]}

Munetsuna, Eiji ^{[4
]}

Ando, Yoshitaka

Teshigawara, Atsushi ^{[6
]}

Ito, Manaka ^{[5
]}

Kageyama, Itsuki ^{[1
]}

Nouchi, Yuki ^{[1
]}

Wakasugi, Takuya ^{[5
]}

Sakakibara, Tomohide ^{[5
]}

Yamazaki, Mirai ^{[7
]}

Ishikawa, Hiroaki ^{[5
]}

Suzuki, Koji ^{[1
]}

Hashimoto, Shuji ^{[3
]}

Ohashi, Koji ^{[5
]}

机构：

[1] Fujita Hlth Univ, Sch Med Sci, Dept Prevent Med Sci, Toyoake, Aichi 4701192, Japan

[2] Tokyo Univ Technol, Sch Hlth Sci, Dept Med Technol, Ota, Tokyo 1448535, Japan

[3] Fujita Hlth Univ, Sch Med, Dept Hyg, Toyoake, Aichi 4701192, Japan

[4] Fujita Hlth Univ, Sch Med, Dept Biochem, Toyoake, Aichi 4701192, Japan

[5] Fujita Hlth Univ, Sch Med Sci, Dept Informat Clin Med, Toyoake, Aichi 4701192, Japan

[6] Fujita Hlth Univ Hosp, Dept Joint Res Lab Clin Med, Toyoake, Aichi 4701192, Japan

[7] Kagawa Prefectural Univ Hlth Sci, Dept Med Technol, Takamatsu, Kagawa 7610123, Japan

来源：

NUTRITION RESEARCH | 2023年 / 110卷

关键词：

High-fructose corn syrup; Mitochondria; Mitochondrial DNA copy number; DNA methylation; Age-specific effect; HIGH-FAT DIETS; SWEETENED BEVERAGES; OXIDATIVE STRESS; LIPID-METABOLISM; RICH DIET; CONSUMPTION; EXPRESSION; LIVER; YOUNG;

D O I：

10.1016/j.nutres.2022.12.010

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

High-fructose corn syrup (HFCS) is consumed worldwide. However, it has been demonstrated that an increased intake of sweetened beverages, including those sweetened using fructose, is associated with the development of childhood obesity. It is unknown why the negative effects of fructose are stronger in young persons than in elderly individuals. In recent years, mitochondria have been identified as 1 of the targets of the negative effects of fructose; they possess their own genome called mitochondrial DNA (mtDNA), which encodes genes involved in metabolic functions. We hypothesized that HFCS intake affects mtDNA in the livers of rats, and that the intensity of these effects is age-dependent. The experimental period was divided into 3 parts: childhood and adolescence (postnatal day [PD] 21-60), young adulthood (PD61-100), and adulthood (PD101-140). Rats in the different age groups were assigned to receive either water (control group [CONT]) or a 20% HFCS solution (HFCS). The hepatic mtDNA copy number of the HFCS group was higher than that of the CONT group in childhood and adolescence. In addition, the mtDNA methylation level

引用

页码：57 / 65

页数：9