Pathogenic role of Th17 cells in autoimmune thyroid disease and their underlying mechanisms

被引：26

作者：

Wang, Yi ^{[1
,2
,3
,4
]}

Fang, Sijie ^{[1
,2
,3
,4
]}

Zhou, Huifang ^{[1
,2
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Ninth Peoples Hosp, Sch Med, Dept Ophthalmol, Shanghai 200011, Peoples R China

[2] Shanghai Key Lab Orbital Dis & Ocular Oncol, Shanghai 200011, Peoples R China

[3] Chinese Consortium Thyroid Eye Dis CCTED, Shanghai, Peoples R China

[4] Shanghai Jiao Tong Univ, Shanghai Inst Immunol, Sch Med, Dept Immunol & Microbiol, Shanghai 200025, Peoples R China

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2023年 / 37卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Th17; cell; Treg imbalance; autoimmune thyroid disease; Graves? disease; Hashimoto?s thyroiditis; REGULATORY T-CELLS; GROWTH-FACTOR-BETA; HASHIMOTOS-THYROIDITIS; TGF-BETA; RHEUMATOID-ARTHRITIS; ORBITAL FIBROBLASTS; GENE-EXPRESSION; GRAVES-DISEASE; SPLICE FORMS; DIFFERENTIATION;

D O I：

10.1016/j.beem.2023.101743

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autoimmune thyroid disease, encompassing Graves' disease and Hashimoto's thyroiditis, has a very complex etiology. Pathogenesis of the disease involves both genetic susceptibility and environmental triggers. Traditionally, imbalance of T helper cell 1 and 2 was thought to result in the immune disorders in Graves' disease and Hashimoto's thyroiditis. However, increasing evidence recently revealed the im-portant role of T helper 17 cell and its relative cellular and secretory components in the pathogenesis and progression of autoimmune thyroid disease. This review is aimed to summarize the published studies on the involvement of T helper 17 cell in autoimmune thyroid disease and discuss the underlying regulatory mechanisms, which could possibly serve as the foundation of discovering new ther-apeutic targets. (c) 2023 Published by Elsevier Ltd.

引用

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