Pathogenic role of Th17 cells in autoimmune thyroid disease and their underlying mechanisms

被引：26
作者：
Wang, Yi [1 ,2 ,3 ,4 ]
Fang, Sijie [1 ,2 ,3 ,4 ]
Zhou, Huifang [1 ,2 ,3 ]
机构：
[1] Shanghai Jiao Tong Univ, Shanghai Ninth Peoples Hosp, Sch Med, Dept Ophthalmol, Shanghai 200011, Peoples R China
[2] Shanghai Key Lab Orbital Dis & Ocular Oncol, Shanghai 200011, Peoples R China
[3] Chinese Consortium Thyroid Eye Dis CCTED, Shanghai, Peoples R China
[4] Shanghai Jiao Tong Univ, Shanghai Inst Immunol, Sch Med, Dept Immunol & Microbiol, Shanghai 200025, Peoples R China
来源：
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2023年 / 37卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Th17; cell; Treg imbalance; autoimmune thyroid disease; Graves? disease; Hashimoto?s thyroiditis; REGULATORY T-CELLS; GROWTH-FACTOR-BETA; HASHIMOTOS-THYROIDITIS; TGF-BETA; RHEUMATOID-ARTHRITIS; ORBITAL FIBROBLASTS; GENE-EXPRESSION; GRAVES-DISEASE; SPLICE FORMS; DIFFERENTIATION;
D O I：
10.1016/j.beem.2023.101743
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Autoimmune thyroid disease, encompassing Graves' disease and Hashimoto's thyroiditis, has a very complex etiology. Pathogenesis of the disease involves both genetic susceptibility and environmental triggers. Traditionally, imbalance of T helper cell 1 and 2 was thought to result in the immune disorders in Graves' disease and Hashimoto's thyroiditis. However, increasing evidence recently revealed the im-portant role of T helper 17 cell and its relative cellular and secretory components in the pathogenesis and progression of autoimmune thyroid disease. This review is aimed to summarize the published studies on the involvement of T helper 17 cell in autoimmune thyroid disease and discuss the underlying regulatory mechanisms, which could possibly serve as the foundation of discovering new ther-apeutic targets. (c) 2023 Published by Elsevier Ltd.
引用
收藏
页数：14
相关论文
共 107 条
[1]   Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells [J].
Acosta-Rodriguez, Eva V. ;
Napolitani, Giorgio ;
Lanzavecchia, Antonio ;
Sallusto, Federica .
NATURE IMMUNOLOGY, 2007, 8 (09) :942-949
[2]   Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17 [J].
Aggarwal, S ;
Ghilardi, N ;
Xie, MH ;
de Sauvage, FJ ;
Gurney, AL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (03) :1910-1914
[3]  
Aggarwal S, 2002, J LEUKOCYTE BIOL, V71, P1
[4]   Autoimmune thyroid disorders [J].
Antonelli, Alessandro ;
Ferrari, Silvia Martina ;
Corrado, Alda ;
Di Domenicantonio, Andrea ;
Fallahi, Poupak .
AUTOIMMUNITY REVIEWS, 2015, 14 (02) :174-180
[5]   The IL15+96522 A>T functional polymorphism is related to the differentiation of Th17 cells and the severity of Hashimoto's disease [J].
Arakawa, Y. ;
Watanabe, M. ;
Takemura, K. ;
Inoue, N. ;
Hidaka, Y. ;
Iwatani, Y. .
INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 2017, 44 (02) :41-50
[6]   Polyfunctional, Pathogenic CD161+ Th17 Lineage Cells Are Resistant to Regulatory T Cell-Mediated Suppression in the Context of Autoimmunity [J].
Basdeo, Sharee A. ;
Moran, Barry ;
Cluxton, Deborah ;
Canavan, Mary ;
McCormick, Jennifer ;
Connolly, Mary ;
Orr, Carl ;
Mills, Kingston H. G. ;
Veale, Douglas J. ;
Fearon, Ursula ;
Fletcher, Jean M. .
JOURNAL OF IMMUNOLOGY, 2015, 195 (02) :528-540
[7]   The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors [J].
Baumann, H ;
Morella, KK ;
White, DW ;
Dembski, M ;
Bailon, PS ;
Kim, HK ;
Lai, CF ;
Tartaglia, LA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (16) :8374-8378
[8]   Foxp3 interacts with nuclear factor of activated T cells and NF-κB to repress cytokine gene expression and effector functions of T helper cells [J].
Bettelli, E ;
Dastrange, M ;
Oukka, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (14) :5138-5143
[9]   Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells [J].
Bettelli, E ;
Carrier, YJ ;
Gao, WD ;
Korn, T ;
Strom, TB ;
Oukka, M ;
Weiner, HL ;
Kuchroo, VK .
NATURE, 2006, 441 (7090) :235-238
[10]   Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt+ Regulatory T Cells and Exacerbate Colitis in Mice [J].
Britton, Graham J. ;
Contijoch, Eduardo J. ;
Mogno, Ilaria ;
Vennaro, Olivia H. ;
Llewellyn, Sean R. ;
Ng, Ruby ;
Li, Zhihua ;
Mortha, Arthur ;
Merad, Miriam ;
Das, Anuk ;
Gevers, Dirk ;
McGovern, Dermot P. B. ;
Singh, Namita ;
Braun, Jonathan ;
Jacobs, Jonathan P. ;
Clemente, Jose C. ;
Grinspan, Ari ;
Sands, Bruce E. ;
Colombel, Jean-Frederic ;
Dubinsky, Marla C. ;
Faith, Jeremiah J. .
IMMUNITY, 2019, 50 (01) :212-+
12345678910