Mechanosensitive Ion Channels and Their Role in Cancer Cells

被引：24
作者：
Karska, Julia [1 ]
Kowalski, Szymon [1 ]
Saczko, Jolanta [2 ]
Moisescu, Mihaela G. G. [3 ]
Kulbacka, Julita [2 ,4 ]
机构：
[1] Wroclaw Med Univ, Fac Med, PL-50345 Wroclaw, Poland
[2] Wroclaw Med Univ, Fac Pharm, Dept Mol & Cellular Biol, PL-50556 Wroclaw, Poland
[3] Carol Davila Univ Med & Pharm, Fac Med, Res Ctr Excellence Biophys & Cellular Biotechnol, Dept Biophys & Cellular Biotechnol, Bucharest 050474, Romania
[4] State Res Inst Ctr Innovat Med, Dept Immunol, LT-08406 Vilnius, Lithuania
来源：
MEMBRANES | 2023年 / 13卷 / 02期
关键词：
mechanosensitive ion channels; piezo channels; mechanoreceptors; cancer; YES-ASSOCIATED PROTEIN; MOLECULAR-MECHANISMS; VANILLOID RECEPTOR; BLOOD-PRESSURE; PIEZO1; PROMOTES; EXPRESSION; MIGRATION; ACTIVATION; INVASION;
D O I：
10.3390/membranes13020167
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mechanical forces are an inherent element in the world around us. The effects of their action can be observed both on the macro and molecular levels. They can also play a prominent role in the tissues and cells of animals due to the presence of mechanosensitive ion channels (MIChs) such as the Piezo and TRP families. They are essential in many physiological processes in the human body. However, their role in pathology has also been observed. Recent discoveries have highlighted the relationship between these channels and the development of malignant tumors. Multiple studies have shown that MIChs mediate the proliferation, migration, and invasion of various cancer cells via various mechanisms. This could show MIChs as new potential biomarkers in cancer detection and prognosis and interesting therapeutic targets in modern oncology. Our paper is a review of the latest literature on the role of the Piezo1 and TRP families in the molecular mechanisms of carcinogenesis in different types of cancer.
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页数：22
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