Brain deficit patterns of metabolic illnesses overlap with those for major depressive disorder: A new metric of brain metabolic disease

被引：3

作者：

Hatch, Kathryn S. ^{[1
]}

Gao, Si ^{[1
]}

Ma, Yizhou ^{[1
]}

Russo, Alessandro ^{[1
]}

Jahanshad, Neda ^{[2
]}

Thompson, Paul M. ^{[2
]}

Adhikari, Bhim M. ^{[1
]}

Bruce, Heather ^{[1
]}

Van Der Vaart, Andrew ^{[1
]}

Sotiras, Aristeidis ^{[3
,4
]}

Kvarta, Mark D. ^{[1
]}

Nichols, Thomas E. ^{[5
]}

Schmaal, Lianne ^{[6
,7
]}

Hong, L. Elliot ^{[1
]}

Kochunov, Peter ^{[1
,8
]}

机构：

[1] Univ Maryland, Maryland Psychiat Res Ctr, Dept Psychiat, Sch Med, Baltimore, MD USA

[2] Stevens Neuroimaging & Informat Inst, Imaging Genet Ctr, Keck Sch Med USC, Marina Del Rey, CA USA

[3] Washington Univ, Inst Informat, Sch Med, St Louis, MO USA

[4] Washington Univ, Sch Med, Dept Radiol, St Louis, MO USA

[5] Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England

[6] Univ Melbourne, Ctr Youth Mental Hlth, Melbourne, Vic, Australia

[7] Orygen, Parkville, Australia

[8] Univ Maryland, Maryland Psychiat Res Ctr, Dept Psychiat, Sch Med, Baltimore, MD 21201 USA

来源：

HUMAN BRAIN MAPPING | 2023年 / 44卷 / 06期

基金：

美国国家卫生研究院; 澳大利亚国家健康与医学研究理事会;

关键词：

brain imaging; major depressive disorder; metabolic disorders; regional vulnerability index; PULSE-WAVE ENCEPHALOPATHY; WHITE-MATTER CHANGES; BLOOD-PRESSURE; COGNITIVE IMPAIRMENT; ELDERLY-PATIENTS; HYPERTENSION; OBESITY; RISK; ANTIDEPRESSANTS; SCHIZOPHRENIA;

D O I：

10.1002/hbm.26235

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Metabolic illnesses (MET) are detrimental to brain integrity and are common comorbidities in patients with mental illnesses, including major depressive disorder (MDD). We quantified effects of MET on standard regional brain morphometric measures from 3D brain MRI as well as diffusion MRI in a large sample of UK BioBank participants. The pattern of regional effect sizes of MET in non-psychiatric UKBB subjects was significantly correlated with the spatial profile of regional effects reported by the largest meta-analyses in MDD but not in bipolar disorder, schizophrenia or Alzheimer's disease. We used a regional vulnerability index (RVI) for MET (RVI-MET) to measure individual's brain similarity to the expected patterns in MET in the UK Biobank sample. Subjects with MET showed a higher effect size for RVI-MET than for any of the individual brain measures. We replicated elevation of RVI-MET in a sample of MDD participants with MET versus non-MET. RVI-MET scores were significantly correlated with the volume of white matter hyperintensities, a neurological consequence of MET and age, in both groups. Higher RVI-MET in both samples was associated with obesity, tobacco smoking and frequent alcohol use but was unrelated to antidepressant use. In summary, MET effects on the brain were regionally specific and individual similarity to the pattern was more strongly associated with MET than any regional brain structural metric. Effects of MET overlapped with the reported brain differences in MDD, likely due to higher incidence of MET, smoking and alcohol use in subjects with MDD.

引用

页码：2636 / 2653

页数：18