Therapeutic angiogenesis and tissue revascularization in ischemic vascular disease

被引：22

作者：

Chen, Xinyue ^{[1
]}

Yu, Wenlu ^{[2
]}

Zhang, Jing ^{[3
]}

Fan, Xiao ^{[3
]}

Liu, Xiao ^{[4
]}

Liu, Qi ^{[5
]}

Pan, Su ^{[5
]}

Dixon, Richard A. F. ^{[5
]}

Li, Pengyang ^{[6
]}

Yu, Peng ^{[1
,7
]}

Shi, Ao ^{[8
,9
]}

机构：

[1] Nanchang Univ, Affiliated Hosp 2, Clin Med Coll 2, Nanchang 330006, Jiangxi, Peoples R China

[2] Nanchang Univ, Sch Ophthalmol & Optometry, Nanchang 330006, Peoples R China

[3] Nanchang Univ, Affiliated Hosp 2, Dept Anesthesiol, Nanchang 330006, Jiangxi, Peoples R China

[4] Sun Yat Sen Univ, Affiliated Hosp 2, Dept Cardiovasc Med, Guangzhou 51000, Guangdong, Peoples R China

[5] Texas Heart Inst, Waf Said Mol Cardiol Res Lab, Houston, TX USA

[6] Virginia Commonwealth Univ, Pauley Heart Ctr, Div Cardiol, Richmond, VA USA

[7] Nanchang Univ, Affiliated Hosp 2, Dept Endocrinol & Metab, Nanchang 330006, Jiangxi, Peoples R China

[8] St George Univ London, Sch Med, London, England

[9] Univ Nicosia, Sch Med, Nicosia, Cyprus

来源：

JOURNAL OF BIOLOGICAL ENGINEERING | 2023年 / 17卷 / 01期

关键词：

Ischemic vascular disease; Therapeutic angiogenesis; Tissue revascularization; Biological therapy; MESENCHYMAL STEM-CELLS; ENDOTHELIAL GROWTH-FACTOR; CRITICAL LIMB ISCHEMIA; CORONARY MICROVASCULAR DYSFUNCTION; ELEVATION MYOCARDIAL-INFARCTION; FOCAL CEREBRAL-ISCHEMIA; GENE-THERAPY; SIGNALING PATHWAY; DOUBLE-BLIND; CARDIOVASCULAR-DISEASE;

D O I：

10.1186/s13036-023-00330-2

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Ischemic vascular disease is a major healthcare problem. The keys to treatment lie in vascular regeneration and restoration of perfusion. However, current treatments cannot satisfy the need for vascular regeneration to restore blood circulation. As biomedical research has evolved rapidly, a variety of potential alternative therapeutics has been explored widely, such as growth factor-based therapy, cell-based therapy, and material-based therapy including nanomedicine and biomaterials. This review will comprehensively describe the main pathogenesis of vascular injury in ischemic vascular disease, the therapeutic function of the above three treatment strategies, the corresponding potential challenges, and future research directions.

引用

页数：20

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