Psychological Distress in Young Adults with Acute Myeloid Leukemia Undergoing Induction Chemotherapy

被引：3

作者：

Lockwood, Bethany J. ^{[1
]}

El-Jawahri, Areej ^{[2
]}

Walker, Alison R. ^{[3
]}

Ehrman, Sarah ^{[1
]}

Russell, Deborah ^{[1
]}

Kale, Sachin S. ^{[1
]}

Gustin, Jillian ^{[1
]}

Bose-Brill, Seuli ^{[4
]}

LeBlanc, Thomas W. ^{[5
]}

Luger, Selina M. ^{[6
]}

Lustberg, Maryam ^{[7
,8
]}

Bhatnagar, Bhavana ^{[3
,9
]}

机构：

[1] Ohio State Univ, Wexner Med Ctr, Div Palliat Med, 1581 Dodd Dr McCampbell Hall 5th Floor, Columbus, OH 43210 USA

[2] Harvard Med Sch, Massachusetts Gen Hosp, Div Hematol & Oncol, Boston, MA 02115 USA

[3] Ohio State Univ, Comprehens Canc Ctr, Div Hematol, Columbus, OH 43210 USA

[4] Ohio State Univ, Wexner Med Ctr, Div Gen Internal Med & Pediat, Columbus, OH 43210 USA

[5] Duke Univ, Sch Med, Div Hematol Malignancies & Cellular Therapy, Durham, NC USA

[6] Univ Penn, Perelman Sch Med, Div Hematol Oncol, Philadelphia, PA 19104 USA

[7] Ohio State Univ, Comprehens Canc Ctr, Div Med Oncol, Columbus, OH 43210 USA

[8] Yale Sch Med, Div Med Oncol, New Haven, CT USA

[9] West Virginia Univ, Canc Inst, Sect Hematol Oncol, Wheeling, WV USA

来源：

JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY | 2023年 / 12卷 / 04期

关键词：

acute myeloid leukemia; induction chemotherapy; psychological distress; anxiety; post-traumatic stress disorder; EARLY PALLIATIVE CARE; QUALITY-OF-LIFE; CANCER SURVIVORS; OUTCOMES; ADOLESCENTS; ISSUES; LUNG; AYA;

D O I：

10.1089/jayao.2022.0082

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Young adults (YAs), aged 18-39 years, with acute myeloid leukemia (AML) navigate life disruptions amid an unpredictable illness trajectory. We conducted a secondary analysis of patient-reported outcomes for hospitalized YAs with high-risk AML receiving intensive chemotherapy, collected during a multisite randomized clinical trial. Of the 160 patients, 14 (8.8%) were YAs. At week 2 of hospitalization, YAs demonstrated significant worse quality of life (beta = -18.27; p = 0.036), higher anxiety (beta = 2.72; p = 0.048), and higher post-traumatic stress disorder (PTSD; beta = 10.34; p = 0.007) compared with older adults. Our analysis demonstrated a longitudinal presence of anxiety and PTSD, suggesting persistent unmet psychological needs for YAs with AML.

引用

页码：592 / 598

页数：7

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