Effectiveness of allergen immunotherapy with house dust mite extract for pediatric bronchial asthma

被引：1

作者：

Hamada, Masaaki ^{[1
]}

Saeki, Keigo ^{[2
]}

Tanaka, Ichiro ^{[1
]}

机构：

[1] Yao Municipal Hosp, Dept Pediat, Osaka, Japan

[2] Nara Med Univ, Sch Med, Dept Epidemiol, Nara, Japan

来源：

IMMUNOTHERAPY | 2024年 / 16卷 / 08期

关键词：

allergen immunotherapy; bronchial asthma; house dust mite; subcutaneous immunotherapy; sublingual immunotherapy; SUBCUTANEOUS IMMUNOTHERAPY; SUBLINGUAL IMMUNOTHERAPY; BASOPHIL ACTIVATION; CHILDHOOD; AGE;

D O I：

10.2217/imt-2024-0024

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Aim: We compared the effectiveness of rush subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) using standardized house dust mite (HDM) extract for pediatric bronchial asthma (BA). Methods: We followed the pediatric BA treatment score during 3 years of treatment. We assessed the median time to no longer requiring long-term control pharmacotherapy (LTCP) for BA (LTCP-free). We compared the outcomes after adjustment for confounding factors and propensity score matching. Results: Patients in the HDM SCIT group achieved the LTCP-free status significantly earlier than those in the HDM SLIT group after adjustment for confounding factors and propensity score matching. Conclusion: Patients treated for pediatric BA with rush HDM SCIT had earlier onset of therapeutic effects than those with HDM SLIT.

引用

页码：539 / 549

页数：11

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