Differential prediction of high-sensitivity cardiac troponin-I, but not N-terminal pro-brain natriuretic peptide, in different pitavastatin doses on cardiovascular events in stable coronary artery disease

被引：1

作者：

Mitsutake, Yoshiaki ^{[1
]}

Ishii, Junnichi ^{[2
,3
]}

Fukumoto, Yoshihiro ^{[1
,17
]}

Ito, Sohei ^{[1
]}

Kashiwabara, Kosuke ^{[4
]}

Uemura, Kouhei ^{[4
]}

Matsuyama, Yutaka ^{[4
]}

Sugiyama, Yoichi ^{[1
]}

Ozaki, Yukio ^{[2
]}

Iimuro, Satoshi ^{[5
]}

Iwata, Hiroshi ^{[6
]}

Sakuma, Ichiro ^{[7
]}

Nakagawa, Yoshihisa ^{[8
]}

Hibi, Kiyoshi ^{[9
]}

Hiro, Takafumi ^{[10
]}

Hokimoto, Seiji ^{[11
]}

Miyauchi, Katsumi ^{[6
]}

Daida, Hiroyuki ^{[6
]}

Shimokawa, Hiroaki ^{[12
]}

Saito, Yasushi ^{[13
]}

Kimura, Takeshi ^{[14
]}

Matsuzaki, Masunori ^{[15
]}

Nagai, Ryozo ^{[16
]}

机构：

[1] Kurume Univ, Div Cardiovasc Med, Sch Med, Kurume, Japan

[2] Fujita Hlth Univ, Dept Cardiol, Sch Med, Toyoake, Japan

[3] Toyota Auto Body Yoshiwara Clin, Toyota, Japan

[4] Univ Tokyo Hosp, Clin Res Promot Ctr, Data Sci Off, Tokyo, Japan

[5] Int Univ Hlth & Welf, Innovat & Res Support Ctr, Tokyo, Japan

[6] Juntendo Univ, Grad Sch Med, Dept Cardiovasc Med, Tokyo, Japan

[7] Caress Sapporo Hokko Mem Clin, Sapporo, Japan

[8] Shiga Univ Med Sci, Dept Cardiovasc Med, Otsu, Japan

[9] Yokohama City Univ, Med Ctr, Div Cardiol, Yokohama, Japan

[10] Nihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, Japan

[11] Kumamoto Municipal Ueki Hosp, Kumamoto, Japan

[12] Int Univ Hlth & Welf, Narita, Japan

[13] Chiba Univ, Chiba, Japan

[14] Kyoto Univ, Dept Cardiovasc Med, Grad Sch Med, Kyoto, Japan

[15] St Hill Hosp, Ube, Japan

[16] Jichi Med Univ, Shimotsuke, Japan

[17] Kurume Univ, Div Cardiovasc Med, Sch Med, 67 Asahi Machi, Kurume 8300011, Japan

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2023年 / 387卷

关键词：

Cardiac biomarker; Statin; Coronary artery disease; Cardiovascular events; STATIN THERAPY; PRIMARY PREVENTION; VASCULAR EVENTS; ROSUVASTATIN; CHOLESTEROL; RISK; PARTICIPANTS; METAANALYSIS; PRAVASTATIN; REGRESSION;

D O I：

10.1016/j.ijcard.2023.131138

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: This study aimed to examine whether high-sensitivity cardiac troponin-I (hsTnI) and N-terminal probrain natriuretic peptide (NT-proBNP) could predict future major adverse cardiovascular events (MACE) in stable coronary artery disease (CAD) patients with high- or low-dose of pitavastatin. Methods: This was a case-cohort analysis of the REAL-CAD study, a randomized trial of high- or low-dose (4 or 1 mg/day) pitavastatin therapy in patients with stable CAD. We examined the MACE risk according to the quartile of hsTnI and NT-proBNP at baseline. Results: A total of 1336 and 1396 patients including 582 MACE cases were randomly examined into the hsTnI and NT-proBNP cohort, respectively. Both higher levels of hsTnI and NT-proBNP at baseline were significantly associated with increased risk of MACE (p < 0.001, respectively). When separately analyzed in statin dose, the higher marker levels were significantly associated with higher MACE risk in all cohorts (p < 0.001 in all cohorts). After multivariable adjustment, hsTnI levels were significantly associated with MACE risk in low-dose statin

引用

页数：11

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