The bioavailability, metabolism and microbial modulation of curcumin-loaded nanodelivery systems

被引：34
作者：
Chang, Ruxin [1 ]
Chen, Liran [1 ]
Qamar, Muhammad [2 ]
Wen, Yanjun [3 ]
Li, Linzheng [3 ]
Zhang, Jiayin [1 ]
Li, Xing [1 ]
Assadpour, Elham [4 ,5 ]
Esatbeyoglu, Tuba [6 ]
Kharazmi, Mohammad Saeed [7 ]
Li, Yuan [1 ]
Jafari, Seid Mahdi [8 ]
机构：
[1] China Agr Univ, Coll Food Sci & Nutr Engn, Res Ctr Food Colloids & Delivery Funct, Beijing 100083, Peoples R China
[2] Bahauddin Zakariya Univ, Fac Food Sci & Nutr, Dept Food Sci & Technol, Multan 60800, Pakistan
[3] Henan Zhongda Hengyuan Biotechnol Stock Co Ltd, Henan Prov Key Lab Nat Pigments, Luohe 462600, Peoples R China
[4] Food Ind Res Co, Gorgan, Iran
[5] Gorgan Univ Agr Sci & Nat Resources, Food & Bionanotech Int Res Ctr Fabiano, Gorgan, Iran
[6] Leibniz Univ Hannover, Inst Food Sci & Human Nutr, Dept Food Dev & Food Qual, Kleinen Felde 30, D-30167 Hannover, Germany
[7] Univ Calif Riverside, Fac Med, Riverside, CA 92679 USA
[8] Gorgan Univ Agr Sci & Nat Resources, Dept Food Mat & Proc Design Engn, Gorgan, Iran
来源：
ADVANCES IN COLLOID AND INTERFACE SCIENCE | 2023年 / 318卷
基金：
中国国家自然科学基金;
关键词：
Curcumin; Nanocarriers; Encapsulation; Gastrointestinal digestion; Bioavailability; SOLID LIPID NANOPARTICLES; I CLINICAL-TRIAL; ORAL DELIVERY; CHEMOPREVENTIVE AGENT; PICKERING EMULSIONS; TISSUE DISTRIBUTION; CELLULAR UPTAKE; STABILITY; PHARMACOKINETICS; PERFORMANCE;
D O I：
10.1016/j.cis.2023.102933
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Curcumin (Cur), the major bioactive component of turmeric (Curcuma longa) possesses many health benefits. However, low solubility, stability and bioavailability restricts its applications in food. Recently, nanocarriers such as complex coacervates, nanocapsules, liposomes, nanoparticles, nanomicelles, have been used as novel strategies to solve these problems. In this review, we have focused on the delivery systems responsive to the environmental stimuli such as pH-responsive, enzyme-responsive, targeted-to-specific cells or tissues, mucus penetrating and mucoadhesive carriers. Besides, the metabolites and their biodistribution of Cur and Cur delivery systems are discussed. Most importantly, the interaction between Cur and their carriers with gut micro biota and their effects of modulating the gut health synergistically were discussed comprehensively. In the end, the biocompatibility of Cur delivery systems and the feasibility of their application in food industry is discussed. This review provided a comprehensive review of Cur nanodelivery systems, the health impacts of Cur nano carriers and an insight into the application of Cur nanocarriers in food industry.
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页数：13
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