Synthesis, Antioxidant, and Antibacterial Potential of New Curcumin-Coumarin Hybrids

被引：0

作者：

Negi, Nidhi ^{[1
]}

Chand, Garima ^{[1
]}

Gahtori, Rekha ^{[2
]}

Upadhyay, Santosh K. ^{[2
]}

Joshi, Penny ^{[1
]}

机构：

[1] Kumaun Univ, Dept Chem, DSB Campus, Naini Tal, Uttarakhand, India

[2] Kumaun Univ, Dept Biotechnol, Bhimtal Campus, Naini Tal, Uttarakhand, India

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2023年 / 33卷 / 02期

关键词：

KEYWORDS; Curcumin; Monocarbonyl curcumin analogs; Anti-inflammatory; Antioxidant; Antibacterial; ANTIINFLAMMATORY ACTIVITY; ANTICANCER ACTIVITY; ANALOGS; 4-HYDROXYCOUMARIN; MECHANISM;

D O I：

10.59467/IJHC.2023.33.183

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

To improve the stability and biological properties of curcumin, its & beta;-diketone is replaced with pharmacologically stable monoketo moiety to yield monocarbonyl analogs of curcumin. In this study, a series of monocarbonyl-curcumin conjugated hybrid analog of curcumin were synthesized using Huisgen cycloaddition 1,3 dipolar addition reaction between an azide and alkyne. The antioxidant activity of compounds was tested using 2,2-diphenylpicrylhydrazyl and ABTS methods. The antibacterial activities were evaluated against bacterial strains Bacillus subtilis and Pseudomonas aeruginosa.

引用

页码：183 / 189

页数：7

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