Neural correlates of perceptual switching and their association with empathy and alexithymia in individuals with and without autism spectrum disorder

被引：3

作者：

Tei, Shisei ^{[1
,2
,3
,4
]}

Itahashi, Takashi ^{[1
]}

Aoki, Yuta Y. ^{[1
]}

Kubota, Manabu ^{[1
,2
,5
]}

Hashimoto, Ryu-ichiro ^{[1
,6
]}

Nakamura, Motoaki ^{[1
,7
]}

Okuzumi, Shoko ^{[8
]}

Takahashi, Hidehiko ^{[1
,2
,8
,9
]}

Ohta, Haruhisa ^{[1
,10
]}

Fujino, Junya ^{[1
,2
,8
]}

机构：

[1] Showa Univ, Med Inst Dev Disabil Res, 6-11-11 Kita Karasuyama,Setagaya Ku, Tokyo, Japan

[2] Kyoto Univ, Grad Sch Med, Dept Psychiat, 54 Shogoin Kawaracho,Sakyo Ku, Kyoto, Japan

[3] Waseda Univ, Inst Appl Brain Sci, 2 579-15 Mikajima, Tokorozawa, Saitama, Japan

[4] Tokyo Int Univ, Sch Human & Social Sci, 2509 Matoba, Kawagoe, Saitama, Japan

[5] Natl Inst Quantum Sci & Technol, Natl Inst Radiol Sci, Dept Funct Brain Imaging, 4-9-1 Anagawa,Inage Ku, Chiba 2638555, Japan

[6] Tokyo Metropolitan Univ, Grad Sch Humanities, Dept Language Sci, 1-1 Minami Osawa, Hachioji, Tokyo, Japan

[7] Kanagawa Psychiat Ctr, 2-5-1 Serigaya, Yokohama, Kanagawa, Japan

[8] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Psychiat & Behav Sci, 1-5-45 Yushima,Bunkyo Ku, Tokyo, Japan

[9] Tokyo Med & Dent Univ, Ctr Brain Integrat Res, 1-5-45 Yushima,Bunkyo Ku, Tokyo, Japan

[10] Showa Univ, Sch Med, Dept Psychiat, 6-11-11 Kita Karasuyama,Setagaya Ku, Tokyo, Japan

来源：

JOURNAL OF PSYCHIATRIC RESEARCH | 2023年 / 164卷

基金：

日本科学技术振兴机构;

关键词：

Alexithymia; Autism; Cognitive flexibility; Empathy; Inferior frontal gyrus; WHITE-MATTER INTEGRITY; TEMPOROPARIETAL JUNCTION; QUOTIENT AQ; BRAIN; ATTENTION; FMRI; SELF; BILINGUALISM; ADOLESCENTS; EFFICIENCY;

D O I：

10.1016/j.jpsychires.2023.06.035

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Individuals with autism spectrum disorder (ASD) often show limited empathy (poor recognition of others' emotions) and high alexithymia (poor recognition of own emotions and external thinking), which can negatively impact their social functioning. Previous experimental studies suggest that alterations in cognitive flexibility play key roles in the development of these characteristics in ASD. However, the underlying neural mechanisms that link cognitive flexibility and empathy/alexithymia are still largely unknown. In this study, we examined the neural correlates of cognitive flexibility via functional magnetic resonance imaging during perceptual taskswitching in typical development (TD) adults and adults with ASD. We also investigated associations between regional neural activity and psychometric empathy and alexithymia scores among these populations. In the TD group, stronger activation of the left middle frontal gyrus was associated with better perceptual switching and greater empathic concern. Among individuals with ASD, stronger activation of the left inferior frontal gyrus was associated with better perceptual switching, greater empathy, and lower alexithymia. These findings will contribute to develop a better understanding of social cognition, and could be informative for the development of new ASD therapies.

引用

页码：322 / 328

页数：7