European Medicinal Chemistry Leaders in Industry (EMCL) - On the Status and Future of Medicinal Chemistry Research in Europe

被引：3

作者：

Ali, Amjad ^{[4
]}

Bauser, Marcus ^{[5
]}

Bertrand, Sophie ^{[6
]}

Blackaby, Wesley ^{[7
]}

Boss, Christoph ^{[8
]}

Bossart, Martin ^{[9
]}

Hall, Adrian ^{[10
]}

Binch, Hayley ^{[11
]}

Czechtizky, Werngard ^{[12
]}

Gijsen, Harrie ^{[13
]}

Haning, Helmut ^{[2
]}

Hartung, Ingo V. ^{[3
]}

Kilburn, Paul ^{[14
]}

Lassalle, Gilbert ^{[15
]}

Luecking, Ulrich ^{[16
]}

Mack, Juergen ^{[17
]}

Missbach, Martin ^{[18
]}

Otsomaa, Leena ^{[19
]}

Torrens, Antoni ^{[20
]}

Wagner, Michael ^{[21
]}

Walter, Magnus ^{[22
]}

Weinstabl, Harald ^{[23
]}

van Hijfte, Luc ^{[24
]}

von Nussbaum, Franz ^{[1
]}

机构：

[1] Nuvisan ICB GmbH, Life Sci Chem, Mullerstr 178, D-13353 Berlin, Germany

[2] Bayer AG, Res & Dev, Drug Discovery Sci, Med Chem, D-42096 Wuppertal, Germany

[3] Merck Healthcare KGaA, Med Chem & Drug Design, Frankfurter Str 250, D-64293 Darmstadt, Germany

[4] Merck & Co Inc, External Discovery Chem, 2000 Galloping Hill Rd, Kenilworth, NJ 07033 USA

[5] Leo Pharma, Res & Early Dev, Global R&D, Ind Pk 55, DK-2750 Ballerup, Denmark

[6] GSK Med Res Ctr, Med Chem, Med Design, R&D, Gunnels Wood Rd, Stevenage SG1 2NY, Herts, England

[7] Servier Res Inst, Drug Design & Small Mol Unit, Chem & Analyt Sci, 125 Chemin Ronde, F-78290 Croissy Sur Seine, France

[8] Idorsia Pharmaceut Ltd, Drug Discovery Chem, Hegenheimermattweg 91, CH-4123 Allschwil Bk, Switzerland

[9] Sanofi, Synthet Med Modal, Ind Pk Hochst G838, D-65926 Frankfurt, Germany

[10] UCB Pharma, Med Chem, Chemin Foriest 1, B-1420 Braine Lalleud, Belgium

[11] F Hoffmann La Roche Ltd, Roche Innovat Ctr Basel, Roche Pharm Res & Early Dev, Med Chem, Grenzacherstr 124, CH-4070 Basel, Switzerland

[12] AstraZeneca, Med Chem, Resp & Immunol, Pepparedsleden 1, S-43183 Gothenburg, Sweden

[13] Janssen Res & Dev, Janssen Pharmaceut NV, Discovery Chem, Therapeut Discovery, Turnhoutseweg 30, B-2340 Beerse, Belgium

[14] Lundbeck, Med Chem & Translat DMPK, Ottiliavej 9, DK-2500 Valby, Denmark

[15] Evotec France SAS, Med Chem, Campus Curie,195 Route Espagne, F-31036 Toulouse, France

[16] FoRx Therapeut, Chem, Lichtstr 35, CH-4056 Basel, Switzerland

[17] Boehringer Ingelheim GmbH & Co KG, Med Chem, Birkendorfer Str 65, D-88400 Biberach, Germany

[18] Novartis Inst BioMed Res NIBR, Global Discovery Chem, CH-4002 Basel, Switzerland

[19] Orion Corp, Orion Pharma, Med Design, R&D, Orionintie 1, Espoo 02200, Finland

[20] ABAC Therapeut SL, Chem Collaborat & Strateg Alliances, Joan XXIII 10, Barcelona 08950, Spain

[21] Dewpoint Therapeut GmbH, Chem & Drug Discovery, Ind Pk Hoechst,G830, D-65926 Frankfurt, Germany

[22] Monte Rosa Therapeut AG, Chem Sci & Proc Dev, Klybeckstr 191,WKL 136-3, CH-4057 Basel, Switzerland

[23] Boehringer Ingelheim GmbH & Co KG, Med Chem, Dr Boehringer Gasse 5-11, A-1121 Vienna, Austria

[24] Symeres, Drug Discovery, Kerkenbos 1013, NL-6546 BB Nijmegen, Netherlands

来源：

CHEMMEDCHEM | 2023年 / 18卷 / 13期

关键词：

Medicinal Chemistry; Drug Discovery; New Modalities; Machine Learning; PROTACs;

D O I：

10.1002/cmdc.202300127

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The status of industrial Medicinal Chemistry was discussed with European Medicinal Chemistry Leaders from large to mid-sized pharma and CRO companies as well as biotechs. The chemical modality space has expanded recently from small molecules to address new challenging targets. Besides the classical SAR/SPR optimization of drug molecules also their 'greenness' has increasing importance. The entire pharma discovery ecosystem has developed significantly. Beyond pharma and academia new key players such as Biotech and integrated CROs as well as Digital companies have appeared and are now to a large extend fueled by VC money. Digitalization is happening everywhere but surprisingly did not change speed and success rates of projects so far. Future Medicinal Chemists will still have to be excellent synthetic chemists but in addition they must be knowledgeable in new computational areas such as data sciences. Their ability to collaborate and to work in teams is key.

引用

页数：9

共 5 条

[1]

[Anonymous], About us

[2] Evolving Outsourcing Landscape in Pharma R&D: Different Collaborative Models and Factors To Consider When Choosing a Contract Research Organization [J].

DeCorte, Bart L. .

JOURNAL OF MEDICINAL CHEMISTRY, 2020, 63 (20) :11362-11367

[3]

efmc, US

[4]

mentorsme, US

[5]

transforming-pharma, US

← 1 →