PrEPare for Work: A Pilot Randomized Controlled Trial of an Intervention to Optimize HIV PrEP Outcomes Among Male Sex Workers

被引：6

作者：

Biello, Katie B. ^{[1
,2
,3
,4
,14
]}

Chan, Philip A. ^{[1
,5
,6
,7
]}

Holcomb, Richard ^{[8
]}

Ndoye, Colleen Daley ^{[8
]}

Valente, Pablo K. ^{[1
,9
]}

Maynard, Michaela ^{[5
,6
]}

Gandhi, Monica ^{[10
]}

Mayer, Kenneth H. ^{[4
]}

Mimiaga, Matthew J. ^{[4
,11
,12
,13
]}

机构：

[1] Brown Univ, Sch Publ Hlth, Dept Behav & Social Sci, Providence, RI 02903 USA

[2] Brown Univ, Sch Publ Hlth, Dept Epidemiol, Providence, RI 02903 USA

[3] Brown Univ, Sch Publ Hlth, Ctr Hlth Promot & Hlth Equ, Providence, RI 02903 USA

[4] Fenway Inst, Fenway Hlth, Boston, MA 02215 USA

[5] Brown Univ, Dept Med, Providence, RI USA

[6] Rhode Isl Publ Hlth Inst, Open Door Hlth, Providence, RI USA

[7] Rhode Isl Dept Hlth, Providence, RI USA

[8] RENEW, Project Weber, Providence, RI USA

[9] Univ Connecticut, Dept Allied Hlth Sci, Waterbury, CT USA

[10] Univ Calif San Francisco, UCSF, Dept Med, Div HIV Infect Dis & Global Med, San Francisco, CA USA

[11] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA USA

[12] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA USA

[13] UCLA Ctr LGBTQ Advocacy Res & Hlth C LARAH, Los Angeles, CA USA

[14] 121 South Main St, Providence, RI 02912 USA

来源：

AIDS AND BEHAVIOR | 2023年 / 27卷 / 10期

基金：

美国国家卫生研究院;

关键词：

Male sex work; HIV; PrEP; Randomized controlled trial; PREEXPOSURE PROPHYLAXIS; ANTIRETROVIRAL PROPHYLAXIS; TRANSACTIONAL SEX; RISK BEHAVIOR; SUBSTANCE USE; DOUBLE-BLIND; MEN; PREVENTION; INFECTION; TENOFOVIR;

D O I：

10.1007/s10461-023-04050-y

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

HIV pre-exposure prophylaxis (PrEP) use is limited among male sex workers, who are at exceptionally high-risk for HIV infection. We developed a theory-informed, two-pronged intervention ("PrEPare-for-Work") to optimize PrEP initiation and adherence among male sex workers, which was preliminarily evaluated in a two-stage pilot randomized controlled trial of 110 male sex workers in the US Northeast. Individuals randomized to the Stage 1 PrEPare-for-Work Case Management arm were three times as likely as those in the standard of care (SOC) arm to initiate PrEP (RR = 2.95, 95% CI = 1.57-5.57). Participants who initiated PrEP and were randomized to the Stage 2 PrEPare-for-Work Adherence Counseling arm had higher rates of prevention-effective adherence (measured via tenofovir in hair) compared to those in the SOC arm (RR = 1.7, 95% CI 0.64-4.77; 55.6% vs. 28.6%, respectively); though not statistically significant. Given the need and the promise of this pilot RCT, further efficacy testing is warranted and should be prioritized.

引用

页码：3294 / 3305

页数：12

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