Excellent Repigmentation of Generalized Vitiligo with Oral Baricitinib Combined with NB-UVB Phototherapy

被引:14
作者
Li, Xinxin [1 ]
Sun, Yifang [1 ]
Du, Juan [1 ]
Wang, Fang [1 ]
Ding, Xiaolan [1 ,2 ]
机构
[1] Peking Univ, Dept Dermatol, Peoples Hosp, Beijing, Peoples R China
[2] Peking Univ, Dept Dermatol, Peoples Hosp, 11 Xizhimen South St, Beijing 100044, Peoples R China
来源
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY | 2023年 / 16卷
关键词
IFN-? signaling pathway; Janus kinase inhibitor; baricitinib; vitiligo;
D O I
10.2147/CCID.S396430
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Vitiligo is an acquired autoimmune skin disorder, clinically characterized by distinct white macules and patches resulting from progressive melanocyte destruction. JAK-STAT pathway plays an important role in the loss of epidermal melanocytes. Baricitinib can block the JAK-STAT pathway and the downstream chemokines as a new JAK1/2 inhibitor. In this report, we describe the successful treatment of 2 patients with oral baricitinib combined with NB-UVB phototherapy, which provides a good alternative and supplementary to treat refractory vitiligo.
引用
收藏
页码:635 / 638
页数:4
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