Excellent Repigmentation of Generalized Vitiligo with Oral Baricitinib Combined with NB-UVB Phototherapy

被引：14

作者：

Li, Xinxin ^{[1
]}

Sun, Yifang ^{[1
]}

Du, Juan ^{[1
]}

Wang, Fang ^{[1
]}

Ding, Xiaolan ^{[1
,2
]}

机构：

[1] Peking Univ, Dept Dermatol, Peoples Hosp, Beijing, Peoples R China

[2] Peking Univ, Dept Dermatol, Peoples Hosp, 11 Xizhimen South St, Beijing 100044, Peoples R China

来源：

CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY | 2023年 / 16卷

关键词：

IFN-? signaling pathway; Janus kinase inhibitor; baricitinib; vitiligo;

D O I：

10.2147/CCID.S396430

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Vitiligo is an acquired autoimmune skin disorder, clinically characterized by distinct white macules and patches resulting from progressive melanocyte destruction. JAK-STAT pathway plays an important role in the loss of epidermal melanocytes. Baricitinib can block the JAK-STAT pathway and the downstream chemokines as a new JAK1/2 inhibitor. In this report, we describe the successful treatment of 2 patients with oral baricitinib combined with NB-UVB phototherapy, which provides a good alternative and supplementary to treat refractory vitiligo.

引用

页码：635 / 638

页数：4

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