Emerging roles of the HECT E3 ubiquitin ligases in gastric cancer

被引：5

作者：

Sun, Aiqin ^{[1
,2
]}

Tian, Xianyan ^{[1
]}

Chen, Yifei ^{[1
]}

Yang, Wannian ^{[1
]}

Lin, Qiong ^{[1
]}

机构：

[1] Jiangsu Univ, Sch Med, Zhenjiang, Peoples R China

[2] Jiangsu Univ, Sch Med, Dept Lab Med, Zhenjiang, Peoples R China

来源：

PATHOLOGY & ONCOLOGY RESEARCH | 2023年 / 29卷

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

gastric cancer; ubiquitination; tumor suppressor; HECT E3 ubiquitin ligases; oncoprotein; EPITHELIAL-MESENCHYMAL TRANSITION; C2; DOMAIN; WW DOMAIN; PROTEIN; NEDD4L; UBR5; INSIGHTS; SMURF1; UBE3C; PROLIFERATION;

D O I：

10.3389/pore.2023.1610931

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gastric cancer (GC) is one of the most pernicious gastrointestinal tumors with extraordinarily high incidence and mortality. Ubiquitination modification of cellular signaling proteins has been shown to play important roles in GC tumorigenesis, progression, and prognosis. The E3 ubiquitin ligase is the crucial enzyme in the ubiquitination reaction and determines the specificity of ubiquitination substrates, and thus, the cellular effects. The HECT E3 ligases are the second largest E3 ubiquitin ligase family characterized by containing a HECT domain that has E3 ubiquitin ligase activity. The HECT E3 ubiquitin ligases have been found to engage in GC progression. However, whether HECT E3 ligases function as tumor promoters or tumor suppressors in GC remains controversial. In this review, we will focus on recent discoveries about the role of the HECT E3 ubiquitin ligases, especially members of the NEDD4 and other HECT E3 ligase subfamilies, in GC.

引用

页数：8

共 93 条

[1] The ubiquitin ligase HectH9 regulates transcriptional activation by myc and is essential for tumor cell proliferation [J].