Plasma inflammatory biomarkers in cerebral small vessel disease: A review

被引：21

作者：

Wan, Shuling ^{[1
,2
]}

Dandu, Chaitu ^{[3
]}

Han, Guangyu ^{[1
,2
]}

Guo, Yibing ^{[1
,2
]}

Ding, Yuchuan ^{[3
]}

Song, Haiqing ^{[1
,2
]}

Meng, Ran ^{[1
,2
,3
,4
]}

机构：

[1] Capital Med Univ, Xuanwu Hosp, Natl Ctr Neurol Disorders, Dept Neurol, Beijing, Peoples R China

[2] Beijing Inst Brain Disorders, Adv Ctr Stroke, Beijing, Peoples R China

[3] Wayne State Univ, Dept Neurosurg, Sch Med, Detroit, MI USA

[4] Capital Med Univ, Xuanwu Hosp, Beijing 100053, Peoples R China

来源：

CNS NEUROSCIENCE & THERAPEUTICS | 2023年 / 29卷 / 02期

基金：

中国国家自然科学基金;

关键词：

cerebral small vessel disease; endothelial dysfunction; imaging features; inflammatory biomarkers; C-REACTIVE PROTEIN; WHITE-MATTER LESIONS; BLOOD-BRAIN-BARRIER; TOTAL HOMOCYSTEINE LEVELS; ENDOTHELIAL-CELL ACTIVATION; ISCHEMIC-STROKE; RISK-FACTORS; COGNITIVE FUNCTION; HYPERINTENSITY VOLUME; PERIVASCULAR SPACES;

D O I：

10.1111/cns.14047

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cerebral small vessel disease (CSVD) is a group of pathological processes affecting small arteries, arterioles, capillaries, and small veins of the brain. It is one of the most common subtypes of cerebrovascular diseases, especially highly prevalent in elderly populations, and is associated with stroke occurrence and recurrence, cognitive impairment, gait disorders, psychological disturbance, and dysuria. Its diagnosis mainly depends on MRI, characterized by recent small subcortical infarcts, lacunes, white matter hyperintensities (WMHs), enlarged perivascular spaces (EPVS), cerebral microbleeds (CMBs), and brain atrophy. While the pathophysiological processes of CSVD are not fully understood at present, inflammation is noticed as playing an important role. Herein, we aimed to review the relationship between plasma inflammatory biomarkers and the MRI features of CSVD, to provide background for further research.

引用

页码：498 / 515

页数：18

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